{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T21:24:23Z","timestamp":1785533063752,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although the traditional understanding is that contact sensitization is less frequent in patients with atopic dermatitis (AD), recent studies have shown similar or higher rates of positive patch\u2010test results in AD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to characterise the pattern of contact sensitization in patients with and without AD and evaluate the association between AD and contact sensitization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a single\u2010center, 10\u2010year retrospective review of patients who underwent patch testing between 2007 and 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 4903 patients (male\u2010to\u2010female ratio\u00a0=\u00a01:1.4; mean age 40.1\u2009years) included. About half (2499, 51.0%) of all patients developed at least one positive reaction. The top five frequent reactions were to nickel sulfate (45.4%), potassium dichromate (16.0%), p\u2010phenylenediamine (13.4%), <jats:italic>Myroxylon pereirae<\/jats:italic> (11.8%), and fragrance mix I (11.2%). The overall prevalence of contact sensitization was not significantly different between patients with or without AD. Patients with AD were less likely to develop contact allergies to budesonide and thiuram mix, and more likely to develop contact allergies to potassium dichromate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Contact sensitization was detected in 50% of patients who were patch tested. Nickel sulfate was the most frequently sensitizing allergen. The prevalence of contact allergies in atopic patients is comparable to that in non\u2010atopic patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14068","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T17:06:04Z","timestamp":1644339964000},"page":"398-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Pattern of contact sensitization in patients with and without atopic dermatitis in an Asian dermatology center"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3726-331X","authenticated-orcid":false,"given":"Charlene","family":"Wee","sequence":"first","affiliation":[{"name":"Department of Dermatology National Skin Centre  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee Hian","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Skin Centre  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiahong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Skin Centre  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yik Weng","family":"Yew","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Skin Centre  Singapore"},{"name":"Lee Kong Chian School of Medicine  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Goon","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Skin Centre  Singapore"},{"name":"Lee Kong Chian School of Medicine  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2014.09.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1989.01670150056006"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0340-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8711-2"},{"issue":"4","key":"e_1_2_10_6_1","first-page":"287","article-title":"Terminology of contact dermatitis","volume":"50","author":"Wilkinson DS","year":"1970","journal-title":"Acta Derm Venereol."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2017.03.009"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12711"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.03.028"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01890.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1995"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000165629"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.0548d.x"},{"issue":"2","key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/ddg.14341","article-title":"Atopic skin diathesis rather than atopic dermatitis is associated with specific contact allergies","volume":"19","author":"Forkel S","year":"2021","journal-title":"J Dtsch Dermatol Ges."},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.6136"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02863.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04754.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.11.003"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e318273a3e0"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.03.054"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01963.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13169"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12043"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-014-0421-0"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12895-016-0047-0"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06845.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13327"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1988.tb02358.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2008.00769.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.10.1329"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.03.012"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12873"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.02.001"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14068","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.14068","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T09:24:49Z","timestamp":1692869089000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.14068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,22]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/cod.14068"],"URL":"https:\/\/doi.org\/10.1111\/cod.14068","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,22]]},"assertion":[{"value":"2021-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}