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The disruption of the skin's homeostasis by exposure to contact sensitizers (CSs) can trigger an inflammatory immune response that results in eczema and allergic contact dermatitis. The recognition of these chemicals depends on the expression of pattern recognition receptors on sentinel skin cells, mainly the innate resident immune cells orchestrating the skin's immune response and involving both oxidative and inflammatory pathways. The main driver of these both pathways is the Nrf2\/Keap1 pathway, a major ubiquitous regulator of cellular oxidative and electrophilic stress, activated in various innate immune cells of the skin, including keratinocytes and epidermal Langerhans cells in the epidermis and dermal dendritic cells in the dermis. Nrf2 also shows a strong protective capacity by downregulating inflammatory pathways. In this review, the important role of Nrf2 in the regulation of the immune response to CSs will be discussed and highlighted.<\/jats:p>","DOI":"10.1111\/cod.14073","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T01:01:39Z","timestamp":1644886899000},"page":"13-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Regulation of the immune response to contact sensitizers by\n                    <scp>Nrf2<\/scp>"],"prefix":"10.1111","volume":"87","author":[{"given":"Romain","family":"Vallion","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, Inserm, Inflammation Microbiome Immunosurveillance  Ch\u00e2tenay\u2010Malabry France"},{"name":"Safety Assessment Department Pierre Fabre Dermo Cosm\u00e9tique  Toulouse 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