{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:15:43Z","timestamp":1768893343482,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An aqueous antiseptic containing \u201cchlorhexidine digluconate\/benzalkonium chloride\/benzyl alcohol\u201d (CBB) is widely used in France. The only previous documented study dealing with allergic contact dermatitis (ACD) to this antiseptic is one small case series in children. The French Vigilance Network for Dermatology and Allergy (REVIDAL\u2010GERDA) has collected many cases in the last few years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the clinical and sensitization profiles of patients diagnosed with ACD to CBB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective study of patients with contact dermatitis to CBB and positive tests to CBB and\/or at least one of its components. All patients had to be tested with all components of CBB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 102 patients (71 adults and 31 children) were included. The lesions were extensive in 63% of patients and 55% had delayed time to diagnosis. CBB patch tests were positive in 93.8% of cases. The allergen was identified in 97% of patients, mainly benzyl alcohol in adults (81.7%) and chlorhexidine digluconate in children (54.8%). About 32.4% of the patients were sensitized to several components.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CBB is a cause of ACD at all ages. The components of the antiseptic should be tested. The sensitization profile seems to be different between adults and children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14085","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T22:09:54Z","timestamp":1645826994000},"page":"62-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Multiple cases of sensitization to an antiseptic containing chlorhexidine digluconate\/benzalkonium chloride\/benzyl alcohol with different profiles of sensitization in adults and children"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1705-4032","authenticated-orcid":false,"given":"Charlotte","family":"Beaumont","sequence":"first","affiliation":[{"name":"Department of Dermatology H\u00f4pital Estaing, CHU Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4034-0395","authenticated-orcid":false,"given":"Anne\u2010Sophie","family":"Darrigade","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital Saint\u2010Andr\u00e9, CHU Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8889-1589","authenticated-orcid":false,"given":"Annick","family":"Barbaud","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique AP\u2010HP.Sorbonne Universit\u00e9, H\u00f4pital Tenon, D\u00e9partement de dermatologie et allergologie  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Collet","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU Dijon\u2010Bourgogne  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7991-3165","authenticated-orcid":false,"given":"Nadia","family":"Raison\u2010Peyron","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital Saint Eloi, CHU Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9501-9331","authenticated-orcid":false,"given":"Jean\u2010Luc","family":"Bourrain","sequence":"additional","affiliation":[{"name":"Department of Pneumology and Allergology CHU Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0465-1241","authenticated-orcid":false,"given":"Haudrey","family":"Assier","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU Henri Mondor  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Giordano\u2010Labadie","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital Larrey, CHU Toulouse  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corina","family":"Bara\u2010Passot","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHM  Le Mans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3679-6613","authenticated-orcid":false,"given":"Brigitte","family":"Milpied","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital Saint\u2010Andr\u00e9, CHU Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2383-3753","authenticated-orcid":false,"given":"Florence","family":"T\u00e9tart","sequence":"additional","affiliation":[{"name":"Department of Allergology, Centre Erik Satie CHU Rouen  Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Armingaud","sequence":"additional","affiliation":[{"name":"Private Dermatology Practice  Orl\u00e9ans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Castelain","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital Jean Minjoz, CHU Besan\u00e7on  Besan\u00e7on France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamia","family":"Benkalfate","sequence":"additional","affiliation":[{"name":"Private Dermatology Practice  Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Boulard","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital Jacques Monod, CH Le Havre  Montivilliers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette","family":"Delaunay","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU Angers  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Mathelier\u2010Fusade","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, AP\u2010HP, H\u00f4pital Tenon D\u00e9partement de dermatologie et allergologie  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Pecquet","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, AP\u2010HP, H\u00f4pital Tenon D\u00e9partement de dermatologie et allergologie  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5661-5993","authenticated-orcid":false,"given":"Pauline","family":"Pralong","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital Nord, CHU Grenoble  La Tronche France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Vital\u2010Durand","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital Edouard Herriot, CHU Lyon  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Genillier Foin","sequence":"additional","affiliation":[{"name":"Private Dermatology Practice  Bayonne France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1257-2578","authenticated-orcid":false,"given":"Marine\u2010Alexia","family":"Lef\u00e8vre","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology CHU Saint\u2010Etienne  Saint Priest\u2010en\u2010Jarrez France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8300-1233","authenticated-orcid":false,"given":"Florence","family":"Hacard","sequence":"additional","affiliation":[{"name":"Department of Allergology and Immunology CHU Lyon Sud  Pierre B\u00e9nite France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2281-9052","authenticated-orcid":false,"given":"Audrey","family":"Nosbaum","sequence":"additional","affiliation":[{"name":"Department of Allergology and Immunology CHU Lyon Sud  Pierre B\u00e9nite France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justine","family":"Pasteur","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital Estaing, CHU Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1778-9904","authenticated-orcid":false,"given":"Aude","family":"Valois","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital d'instruction des arm\u00e9es Sainte Anne  Toulon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Vigan","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital Jean Minjoz, CHU Besan\u00e7on  Besan\u00e7on France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2540-4349","authenticated-orcid":false,"given":"Marie\u2010Christine","family":"Ferrier le Bou\u00ebdec","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital Estaing, CHU Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"REVIDAL\u2010GERDA Network","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.1.147"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)80363-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1999.tb06089.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00479.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01559.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01541.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(05)79557-0"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1978.tb03861.x"},{"issue":"9","key":"e_1_2_10_10_1","first-page":"805","article-title":"Contact dermatitis from hexamidine","volume":"111","author":"Revuz J","year":"1984","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1989.tb03210.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13808"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01890.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01256.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01327.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00331.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000160"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000316"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13091"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13481"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01088.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01178.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1999.tb06175.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00341c.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12562"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1988.tb02839.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2006.0866k.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12487"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12087"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000417"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15140"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01257.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1991.tb01766.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2011.00577.x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13393"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reval.2018.02.110"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2007.06068"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.07.017"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000124"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000640"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14085","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.14085","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:54:34Z","timestamp":1692874474000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.14085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,29]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/cod.14085"],"URL":"https:\/\/doi.org\/10.1111\/cod.14085","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,29]]},"assertion":[{"value":"2021-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}