{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:26:00Z","timestamp":1792653960664,"version":"4.5.0"},"reference-count":77,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["DK045735"],"award-info":[{"award-number":["DK045735"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004569","name":"Ministerstwo Edukacji i Nauki","doi-asserted-by":"publisher","award":["IP2012 0443 72"],"award-info":[{"award-number":["IP2012 0443 72"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004569","name":"Ministerstwo Edukacji i Nauki","doi-asserted-by":"publisher","award":["K\/ZDS\/007123"],"award-info":[{"award-number":["K\/ZDS\/007123"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Obesity is associated with chronic, low\u2010grade inflammation in tissues and predisposes to various complications, including inflammatory skin diseases. However, the link between obesity and contact hypersensitivity (CHS) is not fully understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to determine the influence of obesity on T helper 1 (Th1)\u2013mediated CHS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The activity\/phenotype\/cytokine profile of the immune cells was tested <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. Using quantitative polymerase chain reaction (qPCR) and fecal microbiota transplantation (FMT), we tested the role of a high\u2010fat diet (HFD)\u2013induced gut microbiota (GM) dysbiosis in increasing the effects of CHS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Exacerbated CHS correlates with an increased inflammation\u2010inducing GM in obese mice. We showed a proinflammatory milieu in the subcutaneous adipose tissue of obese mice, accompanied by proinflammatory CD4+ T cells and dendritic cells in skin draining lymph nodes and spleen. Obese interleukin (IL)\u201017A\u2212\/\u2212B6 mice are protected from CHS aggravation, suggesting the importance of IL\u201017A in CHS aggravation in obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Obesity creates a milieu that induces more potent CHS\u2010effector cells but does not have effects on already activated CHS\u2010effector cells. IL\u201017A is essential for the pathogenesis of enhanced CHS during obesity. Our study provides novel knowledge about antigen\u2010specific responses in obesity, which may help with the improvement of existing treatment and\/or in designing novel treatment for obesity\u2010associated skin disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14088","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T10:15:07Z","timestamp":1646216107000},"page":"28-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Obesity aggravates contact hypersensitivity reaction in mice"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8295-3988","authenticated-orcid":false,"given":"Monika","family":"Majewska\u2010Szczepanik","sequence":"first","affiliation":[{"name":"Department of Medical Physiology, Chair of Biomedical Sciences, Institute of Physiotherapy, Faculty of Health Sciences Jagiellonian University Medical College  Krakow Poland"},{"name":"Department of Internal Medicine, Section of Endocrinology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Kowalczyk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Endocrinology Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Chair of Biomedical Sciences, Faculty of Health Sciences Jagiellonian University Medical College  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Marci\u0144ska","sequence":"additional","affiliation":[{"name":"Chair of Biomedical Sciences, Faculty of Health Sciences Jagiellonian University Medical College  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Strz\u0119pa","sequence":"additional","affiliation":[{"name":"Chair of Biomedical Sciences, Faculty of Health Sciences Jagiellonian University Medical College  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz J.","family":"Lis","sequence":"additional","affiliation":[{"name":"Department of Histology Jagiellonian University Medical College  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Susan","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity Cardiff University School of Medicine  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Szczepanik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Endocrinology Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Chair of Biomedical Sciences, Faculty of Health Sciences Jagiellonian University Medical College  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Endocrinology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.284"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.10.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.7.4722"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071966"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.12.6783"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.5"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00391-6"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.6852"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319246"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE\u201014\u20100283"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092450"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/medsci6020032"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1223490"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2011.00180"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2015.04.003"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886\u2010015\u20100671\u2010z"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2018.7"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01459"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.01.008"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0202683"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.608871"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00432"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.033"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.11.052"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000363446"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2009.09400.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0804108"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70489-6"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.144.11.4121"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.6.2129"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1999.00837.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00874"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270131"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1998.00435.x"},{"issue":"11","key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.4049\/jimmunol.149.11.3503","article-title":"Gamma delta T cells assist alpha beta T cells in adoptive transfer of contact sensitivity","volume":"149","author":"Ptak W","year":"1992","journal-title":"J Immunol"},{"issue":"8","key":"e_1_2_10_37_1","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.4049\/jimmunol.154.8.3644","article-title":"\u03b3\u03b4 T cells in normal spleen assist immunized \u03b1\u03b2 T cells in the adoptive cell transfer of contact sensitivity. Effect of Bordetella pertussis, cyclophosphamide, and antibodies to determinants on suppressor cells","volume":"154","author":"Askenase PW","year":"1995","journal-title":"J Immunol"},{"issue":"3","key":"e_1_2_10_38_1","doi-asserted-by":"crossref","first-page":"976","DOI":"10.4049\/jimmunol.156.3.976","article-title":"Immune or normal \u03b3\u03b4 T cells that assist \u03b1\u03b2 T cells in elicitation of contact sensitivity preferentially use V\u03b35 and V\u03b44 variable region gene segments","volume":"156","author":"Ptak W","year":"1996","journal-title":"J Immunol"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.6.3745"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2010.08.006"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.283"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13927"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.24294\/ti.v3.i1.98"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/cdli.1.2.202-205.1994"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/870634"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2353"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15\u20101689"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13046"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1159\/000455840"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00440"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6070068"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.02.012"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00645"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838893"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-013-0063-9"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13046"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102009\u201009\u2010245274"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65260"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807126106"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091844"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1238"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80059-8"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500221"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2002"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13\u20101094"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu4081095"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-011-0001-8"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000322"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127262"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909122107"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.260"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.10.007"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2017.03.004"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198469"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-020-00914-w"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05414"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.316448"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.614218"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.14088","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:54:43Z","timestamp":1692874483000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.14088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,18]]},"references-count":77,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/cod.14088"],"URL":"https:\/\/doi.org\/10.1111\/cod.14088","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,18]]},"assertion":[{"value":"2021-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}