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By far, the most reactions (n\u00a0=\u00a0145) were caused by carbamazepine, followed by amoxicillin, isoniazid, phenytoin, ethambutol, fluindione, phenobarbital, rifampicin, and ceftriaxone; 43 drugs each caused a single case only. The drug classes causing the highest number of reactions were anticonvulsants (39%), beta\u2010lactam antibiotics (20%), antituberculosis agents (11%), non\u2010beta\u2010lactam antibiotics (6%), and iodinated contrast media (5%). The sensitivity of patch testing (percentage of positive reactions) is high for anticonvulsants (notably carbamazepine), beta\u2010lactam antibiotics (notably amoxicillin), and, possibly, iodinated contrast media. Allopurinol and sulfasalazine frequently cause DRESS but never give positive patch tests. Patch testing in DRESS appears to be safe, although mild recurrence of DRESS symptoms, mostly skin reactions, may not be rare. Multiple drug hypersensitivity was found to occur in 16% of all patients, but it is argued that the true frequency is higher. Clinical aspects of DRESS, including diagnosing the disease and identifying culprit drugs (patch tests, intradermal tests, in vitro tests, challenge tests) are also provided, emphasizing the role of patch testing.<\/jats:p>","DOI":"10.1111\/cod.14090","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T04:13:42Z","timestamp":1646194422000},"page":"443-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Patch testing in drug reaction with eosinophilia and systemic symptoms (<scp>DRESS<\/scp>): A literature review"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6666-7292","authenticated-orcid":false,"given":"Anton C.","family":"de Groot","sequence":"first","affiliation":[{"name":"Dermatologist np  Wapserveen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2019.03.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-00416-4"},{"issue":"2","key":"e_1_2_7_4_1","first-page":"139","article-title":"Drug reaction with eosinophilia and systemic symptoms (DRESS): incidence, pathogenesis and management","volume":"16","author":"Shiohara T","year":"2017","journal-title":"Expert Opin Drug Saf"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1201\/9781003158004","volume-title":"Monographs in Contact Allergy, Volume 4. 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