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The role of <jats:italic>FLG<\/jats:italic> status in relation to nickel penetration into the skin remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To elucidate the association between <jats:italic>FLG<\/jats:italic> status and nickel penetration into stratum corneum (SC) in individuals without self\u2010reported history of nickel allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty participants (23 <jats:italic>FLG<\/jats:italic> wt and 17 <jats:italic>FLG<\/jats:italic> null) were exposed to a nickel solution (80\u2009\u03bcg\/cm<jats:sup>2<\/jats:sup>) which was applied onto 2\u2009\u00d7\u20092\u2009cm on their left forearm. After 4\u00a0h, the area was tape\u2010stripped with 10 consecutive tapes. Nickel in each tape was quantified using inductively coupled plasma mass spectrometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average recovered nickel dose was 35%\u201348%. A tendency towards lower recovery was seen in <jats:italic>FLG<\/jats:italic> null carriers compared to <jats:italic>FLG<\/jats:italic> wt carriers, and lower recovery in those with history of skin and\/or respiratory symptoms compared to those without such history. This was however not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>FLG<\/jats:italic> null carriers had less nickel recovered by tape strips compared with <jats:italic>FLG<\/jats:italic> wt carriers and, compared with individuals without a history of skin and\/or respiratory symptoms, indicating higher nickel penetration into SC for <jats:italic>FLG<\/jats:italic> null carriers, but further studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14137","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T02:27:08Z","timestamp":1651026428000},"page":"154-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Nickel penetration into stratum corneum in <i>FLG<\/i> null carriers\u2014A human experimental study"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2131-4896","authenticated-orcid":false,"given":"Anneli","family":"Julander","sequence":"first","affiliation":[{"name":"Unit of Integrative Toxicology, Institute of Environmental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emelie Rietz","family":"Liljedahl","sequence":"additional","affiliation":[{"name":"Division of Occupational and Environmental Medicine, Department of Laboratory Medicine Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Korres de Paula","sequence":"additional","affiliation":[{"name":"Division of Occupational and Environmental Medicine, Department of Laboratory Medicine Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Assarsson","sequence":"additional","affiliation":[{"name":"Division of 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