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We have reviewed European Union (EU) legislations on classification and labelling, biocides and cosmetics, concerning conditions for use of the most used sensitizing preservatives (including formaldehyde\u2010releasing substances, isothiazolinones and parabens). We have analysed temporal trends in their use in non\u2010cosmetic products (tonnes, number of products, concentrations), based on annual reports to the Swedish Products Register 1995\u20132018; and we discuss implications for stakeholders. Major changes over time are that the use of most of the preservatives has increased by tonnes and\/or by number of products, and that several use concentrations have declined following harmonized classification as a skin sensitizer with low concentration limits for this classification. We conclude that the massive increase in use of preservatives is alarming, and that urgent action is needed for protection of health. Their use in non\u2010cosmetic products is broad, increasing and often undisclosed. In the EU, legislations concerning chemicals can provide relevant restrictions to reduce their use and associated health risks, monitored by efficient surveillance. Prevention would be benefited by better coordination between legislations.<\/jats:p>","DOI":"10.1111\/cod.14181","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T02:29:31Z","timestamp":1657160971000},"page":"389-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Preservatives in non\u2010cosmetic products: Increasing human exposure requires action for protection of health"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9951-5896","authenticated-orcid":false,"given":"Carola","family":"Lid\u00e9n","sequence":"first","affiliation":[{"name":"Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9785-7462","authenticated-orcid":false,"given":"Niklas","family":"Andersson","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5048-4635","authenticated-orcid":false,"given":"Ian R.","family":"White","sequence":"additional","affiliation":[{"name":"Cutaneous Allergy, St. John's Institute of Dermatology Guy's Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17072404"},{"key":"e_1_2_10_3_1","first-page":"1","article-title":"Regulation (EU) No 528\/2012 of the European Parliament and of the Council of 22 May 2012 concerning the making available on the market and use of biocidal products","volume":"167","year":"2012","journal-title":"Off J Eur Union"},{"key":"e_1_2_10_4_1","first-page":"1","article-title":"Regulation (EC) No 1272\/2008 of the European Parliament and of the Council of 16 December 2008 on Classification, Labelling and Packaging of substances and mixtures, amending and repealing Directives 67\/548\/EEC and 1999\/45\/EC, and amending Regulation (EC) No 1907\/2006","volume":"353","year":"2008","journal-title":"Off J Eur Union"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.149846"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.03.040"},{"key":"e_1_2_10_7_1","unstructured":"European Chemicals Agency (ECHA).Information on biocides. 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