{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T06:16:49Z","timestamp":1764656209727,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007546","name":"ANSES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007546","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acetophenone azine (CAS no. 729\u201043\u20101) present in sports equipment (shoes, socks and shin pads) has been suspected to induce skin allergies. Twelve case reports of allergy in children and adults from Europe and North America were published between 2016 and 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this study was to confirm that acetophenone azine is indeed a skin sensitizer based on in vitro<jats:italic>\/<\/jats:italic> in vivo testings derived from the Adverse Outcome Pathway (AOP) built for skin sensitization by OECD in 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Acetophenone azine was tested in vitro according to the human cell line activation test (h\u2010CLAT) and the ARE\u2010Nrf2 Luciferase Test (KeratinoSens) and in vivo using the Local Lymph Nodes Assay (LLNA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both the h\u2010CLAT and the KeratinoSens were positive whereas the LLNA performed at 5, 2.5 and 1% (wt\/vol) of acetophenone azine, was negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on these results, acetophenone azine was considered as a skin sensitizer. This was recently confirmed by its classification under the CLP regulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14216","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T17:59:31Z","timestamp":1662659971000},"page":"35-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sensitization properties of acetophenone azine, a new skin sensitizer identified in textile"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0425-7220","authenticated-orcid":false,"given":"Isabelle","family":"Mani\u00e8re","sequence":"first","affiliation":[{"name":"Risk Assessment Department French agency for food, environmental, ocupational health and safety  Maisons\u2010Alfort France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliz\u00e9e","family":"Aubert","sequence":"additional","affiliation":[{"name":"Charles River Laboratories Evreux  Miserey France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Dubois","sequence":"additional","affiliation":[{"name":"Risk Assessment Department French agency for food, environmental, ocupational health and safety  Maisons\u2010Alfort France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cilia","family":"Solal","sequence":"additional","affiliation":[{"name":"Risk Assessment Department French agency for food, environmental, ocupational health and safety  Maisons\u2010Alfort France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9507-0700","authenticated-orcid":false,"given":"Jean\u2010Pierre","family":"Lepoittevin","sequence":"additional","affiliation":[{"name":"Institute of Chemistry UMR 7177 University of Strasbourg, CNRS  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Rousselle","sequence":"additional","affiliation":[{"name":"Risk Assessment Department French agency for food, environmental, ocupational health and safety  Maisons\u2010Alfort France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Anses2018Report\u2014footwear and textile clothing: consumers need better protection from the risks of skin allergies and irritation. Accessed September 21 2022.https:\/\/www.anses.fr\/en\/content\/footwear\u2010and\u2010textile\u2010clothing\u2010consumers\u2010need\u2010better\u2010protection\u2010risks\u2010skin\u2010allergies\u2010and."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12579"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12777"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12843"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000444"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13504"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3281"},{"key":"e_1_2_10_9_1","unstructured":"Anonymous.Study of acetophenone azine hydrolysis in artificial sweat (non GLP).2017."},{"key":"e_1_2_10_10_1","unstructured":"Mombelli E Troise A.INERIS Etat de l'art des outils in silico de sensibilisation cutan\u00e9e [EAT DRC 49 2018] Direction des Risques Chroniques (DRC) P\u00f4le Dangers et Impact sur le Vivant (VIVA) Unit\u00e9 Expertise en Toxicologie\/Ecotoxicologie des Substances Chimiques (ETES) Report DRC\u201018\u2010170857\u201003926A\u2010 21\/01\/2019. 2018."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.18356\/e9e7b6dc-en"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12179"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajcd.2002.34570"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000697"},{"key":"e_1_2_10_15_1","unstructured":"Scientific Committee on Consumer Safety (SCCS).The SCCS notes of guidance for the testing of cosmetic ingredients and their safety evaluation 11TH revision.2021. Accessed October 16 2021.https:\/\/ec.europa.eu\/health\/sites\/default\/files\/scientific_committees\/consumer_safety\/docs\/sccs_o_250.pdf."},{"key":"e_1_2_10_16_1","unstructured":"EFSA.Guidance on dermal absorption. Revision of guidance issued in 2012 from EFSA PPR panel.2017. Accessed September 21 2022.https:\/\/efsa.onlinelibrary.wiley.com\/doi\/epdf\/10.2903\/j.efsa.2017.4873."},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15911"},{"key":"e_1_2_10_18_1","unstructured":"Committee for Risk Assessment RAC.Opinion proposing harmonized classification and labelling at EU level of 1\u2010phenylethan\u20101\u2010one (1\u2010phenylethylidene)hydrazone EC number: 211\u2010979\u20100 CAS number: 729\u201043\u20101 CLH\u2010O\u20100000007030\u201090\u201001\/F.2021. Accessed September 21 2022.https:\/\/echa.europa.eu\/documents\/10162\/406014ba-22c5-4baf-d667-ed7e7faed229."}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.14216","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T09:13:56Z","timestamp":1692522836000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.14216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/cod.14216"],"URL":"https:\/\/doi.org\/10.1111\/cod.14216","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"type":"print","value":"0105-1873"},{"type":"electronic","value":"1600-0536"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"2022-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}