{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:15:21Z","timestamp":1788581721077,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Carvone (l\u2010carvone) is a mint\u2010tasting flavour additive that most of us is exposed to and can cause allergic contact reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To analyse the frequency and the relevance of positive carvone reactions in a dermatitis population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A retrospective analysis of dermatitis patients consecutively tested with carvone from 2017 to 2021. Data were retrieved from the department's patch\u2010test database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 3554 patients tested with carvone, 28 (0.79%) had a positive reaction. Carvone\u2010positive patients had higher mean age, were significantly more likely female (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.001) and had often an intraoral\/lip involvement (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.001). In the carvone\u2010positive group, 50% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200914) had a relevant reaction, and in 4 of 14, the relevance was first revealed after test reading. Of the carvone\u2010positive patients, 18 of 28 did not have a coexisting allergy to a fragrance\/flavour allergen and of these 44% had a relevant allergy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study suggests that a significant fraction of relevant carvone contact allergies may be overlooked if the allergen is not tested. Furthermore, as the exposure is widespread, inclusion of carvone in the Swedish baseline series may be justified even if the contact allergy prevalence is below 1%.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.14249","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T09:44:39Z","timestamp":1668764679000},"page":"206-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The use of carvone in consecutive patch testing"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7363-8265","authenticated-orcid":false,"given":"Johanna","family":"Enberg","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University  Malm\u00f6 Sweden"},{"name":"Helsingborg's Hospital  Helsingborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5188-7711","authenticated-orcid":false,"given":"Nils","family":"Hamnerius","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3984-0210","authenticated-orcid":false,"given":"Liv","family":"Kroona","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Malm\u00f6 University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4797-0269","authenticated-orcid":false,"given":"Cecilia","family":"Svedman","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"American Chemical Society.Accessed March 5 2022.https:\/\/www.acs.org\/content\/acs\/en\/molecule-of-the-week\/archive\/c\/carvone.html"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2014.3806"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-015-1558-x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2022.112975"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12803"},{"key":"e_1_2_9_7_1","first-page":"311","volume-title":"Flavor and Safety","author":"Morcia C","year":"2016"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","unstructured":"BainesD SealR.Natural Food Additives Ingredients and Flavourings Elsevier 2012.245p.","DOI":"10.1533\/9780857095725"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2005.01.003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1992.tb00129.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13766"},{"key":"e_1_2_9_13_1","volume-title":"Manual of Contact Dermatitis","author":"Fregert S","year":"1981"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000741"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1993.tb03511.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3009"},{"key":"e_1_2_9_17_1","unstructured":"Mint Essential Oils Market Size Share & Trends Industry Report 2019\u20102025. Accessed May 20 2022.https:\/\/www.grandviewresearch.com\/industry-analysis\/mint-essential-oils-market"},{"key":"e_1_2_9_18_1","unstructured":"Swedish Match. 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