{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:55:43Z","timestamp":1788191743133,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004892","name":"AECID","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Current frequency and risk factors for sensitization to methylisothiazolinone (MI), methylchloroisothiazolinone\/methylisothiazolinone (MCI\/MI), benzisothiazolinone (BIT) and octylisothiazolinone (OIT) in Spain are not well known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To study the frequency of sensitization, risk factors and simultaneous sensitization between the four isothiazolinones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We analysed all 2019\u20132021 consecutive patients patch\u2010tested with MI (0.2% aq.), MCI\/MI (0.02% aq.), BIT (0.1% pet.) and OIT (0.1% pet) within the Spanish Contact Dermatitis Registry (REIDAC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2511 patients were analysed. Frequencies of sensitization were: any isothiazolinone 15.7%, MI 6.8%, MCI\/MI 4.8%, BIT 3.5% and OIT 0.5%. MI and MCI\/MI sensitization was associated with being occupationally active, hand dermatitis, detergents and age over 40. BIT sensitization was associated with leg dermatitis and age over 40. About one in nine MI\u2010positive patients were positive to BIT, whereas one in five BIT\u2010positive patients were positive to MI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sensitization to MI, MCI\/MI and BIT is still common in Spain, while sensitization to OIT is rare. Currently, sensitization to MI and MCI\/MI seems to be occupationally related. Although its origin is unknown, sensitization to BIT is more frequent in patients aged over 40\u2009years. Simultaneous sensitization between MI and BIT is uncommon.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.14251","type":"journal-article","created":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T07:49:30Z","timestamp":1668930570000},"page":"212-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Sensitization to isothiazolinones in the Spanish Contact Dermatitis Registry (REIDAC): 2019\u20132021 epidemiological situation"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4832-5483","authenticated-orcid":false,"given":"Carlos Pelayo","family":"Hern\u00e1ndez Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Universitario de Gran Canaria Doctor Negr\u00edn, Universidad de Las Palmas de Gran Canaria  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0199-2756","authenticated-orcid":false,"given":"Leopoldo","family":"Borrego","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Insular de Gran Canaria, Universidad de Las Palmas de Gran Canaria  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8309-9725","authenticated-orcid":false,"given":"Pedro","family":"Mercader Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario Jos\u00e9 Mar\u00eda Morales Meseguer  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5434-7753","authenticated-orcid":false,"given":"Ana Mar\u00eda","family":"Gim\u00e9nez Arnau","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar, Instituto Municipal de Investigaci\u00f3n M\u00e9dica  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1240-1015","authenticated-orcid":false,"given":"Javier","family":"S\u00e1nchez P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de La Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8532-6338","authenticated-orcid":false,"given":"Juan Francisco","family":"Silvestre Salvador","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Alicante  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5238-215X","authenticated-orcid":false,"given":"Ricardo","family":"Gonz\u00e1lez P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Araba, Universidad del Pa\u00eds Vasco  Vitoria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5796-7680","authenticated-orcid":false,"given":"Tatiana","family":"Sanz S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Infanta Sof\u00eda  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4941-6405","authenticated-orcid":false,"given":"Araceli","family":"S\u00e1nchez Gilo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Rey Juan Carlos  M\u00f3stoles Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0365-0634","authenticated-orcid":false,"given":"Gemma","family":"Mel\u00e9 Ninot","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Sagrat Cor  Barcelona 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