{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T01:00:25Z","timestamp":1781139625256,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013047","name":"Cultivating Plan Program for the Leader in Science and Technology of Yunnan Province","doi-asserted-by":"publisher","award":["ZX2019\u201003\u201002;2019ZF012;2017HA010"],"award-info":[{"award-number":["ZX2019\u201003\u201002;2019ZF012;2017HA010"]}],"id":[{"id":"10.13039\/501100013047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005329","name":"Natural Science Foundation of Guizhou Province","doi-asserted-by":"publisher","award":["2021\u2010SWJ\u2010002"],"award-info":[{"award-number":["2021\u2010SWJ\u2010002"]}],"id":[{"id":"10.13039\/501100005329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260625"],"award-info":[{"award-number":["82260625"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017947","name":"Postdoctoral Science Foundation of Yunnan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic actinic dermatitis (CAD) is an immune\u2010mediated photo\u2010allergic skin disease. In the clinic, the treatment of this disease is hampered by the lack of proper understanding of the skin barrier dysfunction mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To illuminate the mechanism of skin barrier dysfunction in CAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Transcriptome sequencing and protein profiling were used to detect skin barrier injury\u2010related genes. RNA pull down, a promoter\u2010reporter gene assay, and chromatin isolation by RNA purification\u2010sequencing were used to elucidate the effect of WAKMAR2 in skin barrier functionality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Transcriptome sequencing from patient's tissues showed a significantly decreased expression of WAKMAR2. Down\u2010regulation of WAKMAR2 destroyed the keratinocyte barrier. Moreover, WAKMAR2 can directly bind to the c\u2010Fos protein. This novel long non\u2010coding RNA (LncRNA)\u2010protein complexes were targeted to the CLDN1 promotor. Overexpression of WAKMAR2 enhanced the promoter activity of CLDN1, while the addition of AP\u20101 inhibitor could reverse this phenomenon. Furthermore, our in vivo results suggested that expression of WAKMAR2 was required for the repair of skin damage in mice induced by ultraviolet irradiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We identified a crucial LncRNA (WAKMAR2) for the protection of the skin barrier in vitro and in vivo. Mechanically, it can specifically interact with c\u2010Fos protein for the regulation of CLDN1, a finding which could be applied for CAD treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.14256","type":"journal-article","created":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T01:14:46Z","timestamp":1670030086000},"page":"188-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<scp>LncRNA\u2010WAKMAR2<\/scp>\n                    regulates expression of\n                    <scp>CLDN1<\/scp>\n                    to affect skin barrier through recruiting\n                    <scp>c\u2010Fos<\/scp>"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5860-3985","authenticated-orcid":false,"given":"Yunhua","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Kunming Medical University  Kunming 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 Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Kunming Medical University  Kunming 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