{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:07:52Z","timestamp":1790089672298,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Serious cases of allergic contact dermatitis (ACD) caused by exposure to 3,5,6\u2010tetrachloro\u20104\u2010(methylsulfonyl)pyridine (TCMSP; CAS no. 13108\u201052\u20106) used as an antimicrobial agent for desk mats have been reported in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>A quantitative risk assessment (QRA) of TCMSP contained in desk mats was performed retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A local lymph node assay (LLNA): BrdU\u2010ELISA was conducted to determine a reliable EC1.6 value for TCMSP. The acceptable exposure level (AEL) for TCMSP was derived from the EC1.6 value by applying sensitization assessment factors (SAFs). The exposure level was estimated based on the assumption referring to the use conditions of thiabendazole in the same purpose. Then, the estimated exposure level was compared with the AEL to evaluate the skin sensitization risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The AEL was calculated as 0.00458\u2009\u03bcg\/cm<jats:sup>2<\/jats:sup> based on the EC1.6 value (0.011%, 2.75\u2009\u03bcg\/cm<jats:sup>2<\/jats:sup>) by applying a composite SAF of 600. The estimated TCMSP exposure level from the desk mat was 500 times greater than the AEL, indicating a serious skin sensitization risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Assessments of skin sensitization potencies of chemicals to be used in consumer products are strongly recommended, and QRAs should be performed at the pre\u2010marketing stage to avoid the skin sensitization risk in consumers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14294","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T17:51:13Z","timestamp":1676742673000},"page":"395-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Retrospective quantitative risk assessment of skin sensitization caused by an antimicrobial agent used in a consumer product: 2,3,5,6\u2010Tetrachloro\u20104\u2010(methylsulfonyl) pyridine"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8913-3173","authenticated-orcid":false,"given":"Asako","family":"Fukushima","sequence":"first","affiliation":[{"name":"Chemicals Assessment and Research Center Chemicals Evaluation and Research Institute, Japan  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisako","family":"Morioka","sequence":"additional","affiliation":[{"name":"CERI Hita Chemicals Evaluation and Research Institute, Japan  Hita\u2010shi Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"CERI Hita Chemicals Evaluation and Research Institute, Japan  Hita\u2010shi Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritsuko","family":"Katagiri","sequence":"additional","affiliation":[{"name":"Chemicals Assessment and Research Center Chemicals Evaluation and Research Institute, Japan  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiko","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Chemicals Assessment and Research Center Chemicals Evaluation and Research Institute, Japan  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Sakunaga","sequence":"additional","affiliation":[{"name":"Chemicals Assessment and Research Center Chemicals Evaluation and Research Institute, Japan  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Takeyoshi","sequence":"additional","affiliation":[{"name":"Chemicals Assessment and Research Center Chemicals Evaluation and Research Institute, Japan  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1","article-title":"Preventive measures against health damage due to chemicals in household products","volume":"124","author":"Kaniwa M","year":"2006","journal-title":"Bull Natl Inst Health Sci"},{"key":"e_1_2_9_3_1","unstructured":"National Institute of Technology and Evaluation.Retrieval of accident information. 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