{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T17:40:54Z","timestamp":1779903654158,"version":"3.53.1"},"reference-count":68,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Benzisothiazolinone (BIT; CAS no. 2634\u201033\u20105) is used as a biocide in various products, including water\u2010based paints, metalworking fluids, and household products. In recent years, increasing sensitization rates have been observed in Europe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe a time trend of sensitization to BIT, analyse concomitant reactions, and identify patients with increased risk of BIT sensitization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of data from 26\u2009739 patients patch tested with BIT, sodium salt, 0.1% petrolatum as part of several special test series within the Information Network of Departments of Dermatology (IVDK), 2002 to 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Positive reactions to BIT were noted in 771 patients (2.9%). Sensitization frequency varied over time and increased in recent years, peaking at 6.5% in 2020. Painters and metalworkers handling metalworking fluids, but not cleaners, had a significantly increased risk of BIT sensitization. From our data, there is no evidence of immunological cross\u2010reactivity between BIT and other isothiazolinones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The increasing frequency of sensitization justifies adding BIT to the baseline series. More research on the clinical relevance of positive patch test reactions to BIT and the cause for the rising numbers of BIT sensitization is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14300","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T11:41:32Z","timestamp":1677757292000},"page":"446-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Contact sensitization to benzisothiazolinone: <scp>IVDK<\/scp>\u2010data of the years 2002 to 2021"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5047-8948","authenticated-orcid":false,"given":"Johannes","family":"Geier","sequence":"first","affiliation":[{"name":"Information Network of Departments of Dermatology (IVDK) Institute at the University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"Lower Saxony Institute of Occupational Dermatology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1245-024X","authenticated-orcid":false,"given":"Richard","family":"Brans","sequence":"additional","affiliation":[{"name":"Institute for Interdisciplinary Dermatologic Prevention and Rehabilitation (iDerm) University of Osnabr\u00fcck  Osnabr\u00fcck Germany"},{"name":"Department of Dermatology, Environmental Medicine and Health Theory University of Osnabr\u00fcck  Osnabr\u00fcck Germany"},{"name":"Lower Saxony Institute of Occupational Dermatology University of Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7016-0224","authenticated-orcid":false,"given":"Elke","family":"Weisshaar","sequence":"additional","affiliation":[{"name":"Unit for Occupational Dermatology, Department of Dermatology Ruprecht\u2010Karls University  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6040-9305","authenticated-orcid":false,"given":"Nicola","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Friedrich\u2010Alexander University of Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Szliska","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bethesda Hospital  Freudenberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9231-9865","authenticated-orcid":false,"given":"Annice","family":"Heratizadeh","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Division of Immunodermatology and Allergy Research Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2359-2518","authenticated-orcid":false,"given":"Steffen","family":"Schubert","sequence":"additional","affiliation":[{"name":"Information Network of Departments of Dermatology (IVDK) Institute at the University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"Lower Saxony Institute of Occupational Dermatology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the IVDK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"European Chemicals Agency.Substance infocard 1 2\u2010benzisothiazol\u20103(2H)\u2010one. 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