{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:57:00Z","timestamp":1791644220134,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The mint flavour carvone (l\u2010carvone) is considered a weak contact allergen. However, contact allergy to carvone is more prevalent in patients with oral lichen planus or oral lichenoid lesions (OLP\/OLL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our aim was to investigate how carvone affects sensitized individuals through a use test with toothpaste containing carvone. Non\u2010flavoured toothpaste served as control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects were patch tested prior to the use test\u201414 subjects allergic to carvone (11 with OLP\/OLL), 20 subjects with OLP\/OLL and 3 healthy controls. The month\u2010long use test comprised of using toothpaste twice daily. Subjects were examined fortnightly. Clinical signs were assessed with a mucosal scoring system. The subjects' oral health\u2010related quality of life was measured with the oral health impact profile (OHIP\u201049).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Local reactions to the carvone toothpaste presented as aggravated OLL (7\/10) and peri\u2010oral eczema (2\/10) in allergic subjects. They also had significantly higher mucosal and OHIP scores compared with those receiving non\u2010flavoured toothpaste.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In sensitized individuals, oral exposure to carvone gives aggravated oral lesions and\/or peri\u2010oral eczema. The lesions mimic OLP and allergic individuals are therefore at risk of not being assessed with regard to flavour contact allergy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14302","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T04:14:50Z","timestamp":1679026490000},"page":"463-471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Use test with l\u2010carvone in toothpaste on sensitized individuals"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3984-0210","authenticated-orcid":false,"given":"Liv","family":"Kroona","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Faculty of Odontology Malm\u00f6 University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Ahlgren","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Folktandv\u00e5rden Sk\u00e5ne, Region Sk\u00e5ne  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Dahlin","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University and Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9005-0962","authenticated-orcid":false,"given":"Marl\u00e9ne","family":"Isaksson","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University and Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-3227","authenticated-orcid":false,"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University and Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010013\u20100950\u20102"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1992.tb00129.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12803"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1993.tb03511.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12637"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/der.0000000000000741"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14249"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20103009"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.00905.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105\u20101873.2004.0459f.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000112"},{"issue":"4","key":"e_1_2_9_13_1","first-page":"553","article-title":"Contact allergy in the mouth: diversity of clinical presentations and diagnosis of common allergens relevant to dental practice","volume":"50","author":"Bakula A","year":"2011","journal-title":"Acta Clin Croat"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100528.1987.tb00480.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.03.011"},{"issue":"7","key":"e_1_2_9_16_1","first-page":"E310","article-title":"Oral lichen planus and oral lichenoid lesions; 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