{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:18Z","timestamp":1787014038257,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023331","name":"LEO Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2023,7]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Measuring patient\u2010reported outcomes is crucial to fully capture the burden of chronic hand eczema (CHE).<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To assess the effect of delgocitinib cream on itch, pain and nine additional key signs and symptoms reported by patients with CHE using the Hand Eczema Symptom Diary (HESD).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In a double\u2010blind, phase IIb dose\u2010ranging trial (NCT03683719), 258 adults with mild to severe CHE were randomized to delgocitinib cream 1, 3, 8 or 20\u2009mg\/g or cream vehicle twice daily for 16\u2009weeks. Patients assessed 11 signs and symptoms of CHE daily through the HESD using an 11\u2010point numeric rating scale; this was an exploratory endpoint.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Delgocitinib cream 20\u2009mg\/g was associated with an early and sustained reduction in itch and pain, along with clinically relevant reductions of \u22654 points from baseline to Week 16 in 48.4% and 63.6% of patients, respectively (17.9% and 5.9% with cream vehicle). There were improvements versus cream vehicle in all assessed CHE signs and symptoms (20\u2009mg\/g,\n p<\/jats:italic>\n \u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Delgocitinib cream reduced itch, pain and other signs and symptoms in patients with CHE. This data correlated with clinician\u2010reported outcomes, indicating that the HESD may be a useful assessment tool for CHE management.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cod.14303","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T21:55:00Z","timestamp":1681163700000},"page":"46-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Treatment with delgocitinib cream improves itch, pain and other signs and symptoms of chronic hand eczema: Results from the Hand Eczema Symptom Diary in a phase\n IIb<\/scp>\n randomized clinical trial"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4411-3088","authenticated-orcid":false,"given":"Andrea","family":"Bauer","sequence":"first","affiliation":[{"name":"Department of Dermatology, University Allergy Center, University Hospital Carl Gustav Carus Technical University Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Bispebjerg Hospital, University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3139-129X","authenticated-orcid":false,"given":"Timo","family":"Buhl","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Georg August University G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor Sch\u00fctt Svane","family":"Nielsen","sequence":"additional","affiliation":[{"name":"LEO Pharma A\/S Ballerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9374-2196","authenticated-orcid":false,"given":"Lotte Seiding","family":"Larsen","sequence":"additional","affiliation":[{"name":"LEO Pharma 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