{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:49:44Z","timestamp":1782125384683,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The two dialkylthiocarbamyl benzothiazole sulphides, dimethyl\u2010thiocarbamylbenzothiazole sulphide (DMTBS) and diethylthio\u2010carbamylbenzothiazole sulphide (DETBS) were shown to be good markers of both thiuram and mercaptobenzothiazole sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate if DMTBS and\/or DETBS could be better markers of contact allergy to common rubber additives than the ones currently used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010eight dermatitis patients were patch tested with DMTBS and DETBS, both at 1% in petrolatum (pet). Because of late reactions in 10 patients, these were retested to DMTBS and DETBS in serial dilutions. Tetramethylthiuram monosulphide (TMTM) 1.0% pet was also tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the initial reading Days 3 and 7, no reactions were noted to DMTBS or DETBS. At retesting, 10 of the 68 (15%) patients reacted positively to lower concentrations of DMTBS than the initial test concentration. Seven of 8 also reacted to TMTM. Three of them had positive reactions to DEBTS. All 10 patients had reactions to more diluted solutions to DMBTS than to DEBTS (<jats:italic>p<\/jats:italic>\u2009=\u20090.0077; Mc\u2010Nemar test, two\u2010sided).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results speak for patch test sensitization to DMTBS with cross\u2010reactivity to TMTM and also DEBTS. DMTBS and DEBTS could be new markers of rubber allergy but a safe test concentration must be found.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14311","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T14:25:16Z","timestamp":1680013516000},"page":"472-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Active sensitization to dimethylthiocarbamylbenzothiazol sulphide: An unexpectedly strong rubber contact allergen"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9005-0962","authenticated-orcid":false,"given":"Marl\u00e9ne","family":"Isaksson","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Skane University Hospital, Lund University  SE\u2010205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Bergendorff","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Skane University Hospital, Lund University  SE\u2010205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5188-7711","authenticated-orcid":false,"given":"Nils","family":"Hamnerius","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Skane University Hospital, Lund University  SE\u2010205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Pont\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Skane University Hospital, Lund University  SE\u2010205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4797-0269","authenticated-orcid":false,"given":"Cecilia","family":"Svedman","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Skane University Hospital, Lund University  SE\u2010205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inese","family":"Hauksson","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Skane University Hospital, Lund University  SE\u2010205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-3227","authenticated-orcid":false,"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Skane University Hospital, Lund University  SE\u2010205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12736"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.219"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.2012.02139.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5254\/1.3547419"},{"issue":"7","key":"e_1_2_9_6_1","first-page":"590","article-title":"Gross D. reaction\u2010products formed during accelerated vulcanization .2. 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