{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:37:37Z","timestamp":1790879857769,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hydroperoxides of limonene (Lim\u2010OOHs) and linalool (Lin\u2010OOHs) are potent contact sensitizers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the prevalence of positive patch test (PT) reactions to Lim\u2010OOHs and Lin\u2010OOHs in consecutive patients, their demographic factors and concomitant reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 7\/2018 and 12\/2020, Lim\u2010OOHs 0.3% pet. and Lin\u2010OOHs 1% pet. were patch tested in 5511 consecutive patients. We assessed PT reactivity and analysed data from patients with either positive or negative PTs to Lim\u2010OOHs and Lin\u2010OOHs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Positive PT results to Lim\u2010OOHs (<jats:italic>n<\/jats:italic>\u2009=\u2009170, 3.1%) and Lin\u2010OOHs (<jats:italic>n<\/jats:italic>\u2009=\u2009483, 8.8%) were frequent. Most of the positive reactions were weak (LimOOHs <jats:italic>n<\/jats:italic>\u2009=\u2009134\/LinOOHs <jats:italic>n<\/jats:italic>\u2009=\u2009429), and even more frequently, doubtful (<jats:italic>n<\/jats:italic>\u2009=\u2009252\/<jats:italic>n<\/jats:italic>\u2009=\u2009578) or irritant reactions (<jats:italic>n<\/jats:italic>\u2009=\u200981\/<jats:italic>n<\/jats:italic>\u2009=\u2009178) were documented. PT reactivity to Lim\u2010OOHs and Lin\u2010OOHs was increased in patients with irritant reactions to sodium lauryl sulphate (SLS). The proportion of leg dermatitis and concomitant positive reactions to fragrances and essential oils was increased in patients with reactivity to these hydroperoxides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The observed reaction pattern suggests that both test preparations display an irritant potential with an increased risk of false positive reactions. Preparations should be chemically monitored in order to reduce irritancy. Mindful interpretation of PT results and aimed patch testing of lower concentrations is recommended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14332","type":"journal-article","created":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T05:50:25Z","timestamp":1683957025000},"page":"85-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Patch testing hydroperoxides of limonene and linalool in consecutive patients\u2014Results of the IVDK 2018\u20132020"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2359-2518","authenticated-orcid":false,"given":"Steffen","family":"Schubert","sequence":"first","affiliation":[{"name":"Information Network of Departments of Dermatology (IVDK) Institute at the University Medical Centre G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5047-8948","authenticated-orcid":false,"given":"Johannes","family":"Geier","sequence":"additional","affiliation":[{"name":"Information Network of Departments of Dermatology (IVDK) Institute at the University Medical Centre G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1245-024X","authenticated-orcid":false,"given":"Richard","family":"Brans","sequence":"additional","affiliation":[{"name":"Institute for Interdisciplinary Dermatologic Prevention and Rehabilitation (iDerm) at the University of Osnabr\u00fcck  Osnabr\u00fcck Germany"},{"name":"Department of Dermatology, Environmental Medicine, and Health Theory University of Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9231-9865","authenticated-orcid":false,"given":"Annice","family":"Heratizadeh","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Division of Immunodermatology and Allergy Research Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birger","family":"Kr\u00e4nke","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5725-7734","authenticated-orcid":false,"given":"Axel","family":"Schnuch","sequence":"additional","affiliation":[{"name":"Information Network of Departments of Dermatology (IVDK) Institute at the University Medical Centre G\u00f6ttingen  G\u00f6ttingen 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University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Vieluf","sequence":"additional","affiliation":[{"name":"Department of Allergology, Photodermatology and Occupational Dermatology Dermatologikum Hamburg  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6040-9305","authenticated-orcid":false,"given":"Nicola","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erlangen University Hospital, Friedrich\u2010Alexander\u2010University of Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3449-1245","authenticated-orcid":false,"given":"Margitta","family":"Worm","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Dermatology, Venereology and Allergy 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