{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T12:29:32Z","timestamp":1775478572662,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Antioxidants in medical devices, added to protect polymers or adhesives, may also cause contact dermatitis in some individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To present data on sensitization to 4,4\u2032\u2010thiobis(2\u2010tert\u2010butyl\u20105\u2010methylphenol), an antioxidant detected in some types of medical devices, for six patients that experienced eczematous reactions to different medical devices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patch testing with 4,4\u2032\u2010thiobis(2\u2010tert\u2010butyl\u20105\u2010methylphenol), 1% pet was performed. Gas chromatography\u2010mass spectrometry (GC\u2010MS) was used for identification of 4,4\u2032\u2010thiobis(2\u2010tert\u2010butyl\u20105\u2010methylphenol) in different medical device products.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six patients with contact allergy to 4,4\u2032\u2010thiobis(2\u2010tert\u2010butyl\u20105\u2010methylphenol) also had relevant contact allergic reactions to medical devices containing the antioxidant. The presence of the antioxidant in products was detected using GC\u2010MS analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The antioxidant 4,4\u2032\u2010thiobis(2\u2010tert\u2010butyl\u20105\u2010methylphenol) may cause allergic contact dermatitis after exposure to different medical devices.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14335","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T04:54:55Z","timestamp":1684299295000},"page":"103-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["4,4\u2032\u2010Thiobis(2\u2010tert\u2010butyl\u20105\u2010methylphenol), an antioxidant in medical devices that may cause allergic contact dermatitis"],"prefix":"10.1111","volume":"89","author":[{"given":"Annarita","family":"Antelmi","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Lejding","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-3227","authenticated-orcid":false,"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6172-9274","authenticated-orcid":false,"given":"Martin","family":"Mowitz","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Dahlin","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70006-N"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476910701680236"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-45395-3_12"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13663"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000861"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13781"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13013"},{"key":"e_1_2_9_9_1","first-page":"3090","volume-title":"Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens","author":"Pohanish RP","year":"2012"},{"key":"e_1_2_9_10_1","unstructured":"European Chemical Agency.ECHA substance infocard: 6 6\u2032\u2010di\u2010tert\u2010butyl\u20104 4\u2032\u2010thiodi\u2010m\u2010cresol.2023. Accessed April 14 2023.https:\/\/echa.europa.eu\/sv\/substance-information\/-\/substanceinfo\/100.002.297"},{"key":"e_1_2_9_11_1","unstructured":"European Chemical Agency.Registration Dossier ECHA: 6 6\u2032\u2010di\u2010tert\u2010butyl\u20104 4\u2032\u2010thiodi\u2010m\u2010cresol.2023. Accessed April 14 2023.https:\/\/echa.europa.eu\/sv\/registration-dossier\/-\/registered-dossier\/16037\/7\/5\/2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13044"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/BJOA.BJOA_69_20"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14084"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/DERM.0000000000000946"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T08:34:21Z","timestamp":1702974861000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.14335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/cod.14335"],"URL":"https:\/\/doi.org\/10.1111\/cod.14335","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,16]]},"assertion":[{"value":"2023-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}