{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:54:26Z","timestamp":1747184066925,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prophylactic vaccination against influenza and other epidemic viruses is recommended for citizens above 65\u2009years. Several vaccines may contain traces of formaldehyde and are contra\u2010indicated in patients hypersensitive (in the broadest possible meaning) to formaldehyde. Thorough knowledge on the various subtypes of hypersensitivity is sparse among non\u2010dermatologists and non\u2010allergists, and therefore many patients are prevented from vaccination based on a positive patch test to formaldehyde. The purpose of this retrospective study was to investigate whether patients with positive patch test to formaldehyde subsequently receiving a formaldehyde\u2010containing vaccine and developed a severe adverse reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\/Materials<\/jats:title><jats:p>From January 2000 to June 2021, 169 patients (&gt;50\u2009years) had a positive formaldehyde patch test at the Department of Dermatology and Allergy Center, Odense University Hospital and were included into this retrospective study. The electronic medical record was assessed for receipt of a formaldehyde\u2010containing vaccine after patch test and for subsequent contact with the Acute Ward in the Region of Southern Denmark within 14\u2009days after vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 158 patients residing in the Region of Southern Denmark, 130 patients were vaccinated with one or more formaldehyde\u2010containing vaccines of whom 123 received an influenza vaccine. No contacts to the acute wards were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Although prospective studies would be beneficial, patients with positive patch test to formaldehyde can be safely vaccinated with formaldehyde\u2010containing vaccines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14350","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T06:35:21Z","timestamp":1684996521000},"page":"107-110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Patients with positive patch test to formaldehyde can be safely vaccinated with formaldehyde\u2010containing vaccines"],"prefix":"10.1111","volume":"89","author":[{"given":"Ulla","family":"Bindslev\u2010Jensen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy, Odense Research Center for Anaphylaxis (ORCA) Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte G.","family":"Mortz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Odense Research Center for Anaphylaxis (ORCA) Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6181-824X","authenticated-orcid":false,"given":"Klaus E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Odense Research Center for Anaphylaxis (ORCA) Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Bindslev\u2010Jensen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Odense Research Center for Anaphylaxis (ORCA) Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14089"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90397-1"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475415582306"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1984.tb00343.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12762"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e31825228cf"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2022.43.210105"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.6.1394"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01025.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T08:34:03Z","timestamp":1702974843000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.14350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,24]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/cod.14350"],"URL":"https:\/\/doi.org\/10.1111\/cod.14350","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"type":"print","value":"0105-1873"},{"type":"electronic","value":"1600-0536"}],"subject":[],"published":{"date-parts":[[2023,5,24]]},"assertion":[{"value":"2023-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}