{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T19:37:19Z","timestamp":1775590639432,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T00:00:00Z","timestamp":1693094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Parthenium dermatitis is the commonest form of plant dermatitis in India, caused by the plant <jats:italic>Parthenium hysterophorus<\/jats:italic>. Systemic immunosuppressives are commonly employed in its treatment. However, there is a relative lack of comparative head\u2010to\u2010head trials. This study was done to assess the relative efficacy and safety of systemic treatments in Parthenium dermatitis. We systematically reviewed all the published studies investigating the safety and efficacy of systemic treatments for Parthenium dermatitis in the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, and clinical trial registries. Treatment benefit data were tabulated based on outcome measures of scoring systems. The quality of evidence for each outcome was assessed by Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria for meta\u2010analysis. The pooled Standardized mean difference (SMD) for case series and comparative studies based on clinical severity score (CSS) for azathioprine was 4.007 (95% CI (Confidence interval): 3.141, 4.873) and 0.746 (95% CI: 0.139, 1.352), respectively. About 88.8% (95% CI: 76.8%, 100.8%, <jats:italic>p\u2009=<\/jats:italic>\u20090.076) of the patients had excellent or a good response to azathioprine. Our meta\u2010analysis shows that azathioprine has the highest level of evidence in the treatment of Parthenium dermatitis.<\/jats:p>","DOI":"10.1111\/cod.14406","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:54:12Z","timestamp":1693184052000},"page":"311-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Systemic treatments in Parthenium dermatitis: A systematic review and <scp>meta\u2010analysis<\/scp>"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2441-5954","authenticated-orcid":false,"given":"Rojita","family":"Akham","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4772-6648","authenticated-orcid":false,"given":"Riti","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9759-4153","authenticated-orcid":false,"given":"Amity","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Community and Family Medicine All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajeet Singh","family":"Bhadoria","sequence":"additional","affiliation":[{"name":"Department of Community and Family Medicine All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Pathak","sequence":"additional","affiliation":[{"name":"O'Deniall Jr School of public health UT Southwestern  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neirita","family":"Hazarika","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.440107-16.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12411"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_9_5_1","first-page":"343","article-title":"The Cochrane collaboration's tool for assessing risk of bias in randomized trials","volume":"18","author":"Higgins JP","year":"2011","journal-title":"BMJ"},{"key":"e_1_2_9_6_1","first-page":"355","article-title":"ROBINS\u2010I: a tool for assessing risk of bias in non\u2010randomized studies of interventions","volume":"12","author":"Sterne JA","year":"2016","journal-title":"BMJ"},{"key":"e_1_2_9_7_1","unstructured":"https:\/\/jbi.global\/sites\/default\/files\/2019-05\/JBI_Critical_Appraisal-Checklist_for_Case_Reports2017_0.pdf. Accessed September 10 2022."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7454.1490"},{"key":"e_1_2_9_9_1","unstructured":"http:\/\/www.cebm.brown.edu\/openmeta\/download.html.pdf. Accessed September 15 2022."},{"key":"e_1_2_9_10_1","unstructured":"https:\/\/handbook-5-1.cochrane.org\/chapter_9\/9_7_sensitivity_analyses.htm. Accessed September 17 2022."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.00950.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.154788"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.19713"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.107647"},{"issue":"1","key":"e_1_2_9_15_1","article-title":"Single blind randomized controlled trial of \u2018Azathioprine versus corticosteroids in Parthenium hysterophorus induced contact dermatitis","volume":"1","author":"Davis SV","year":"2015","journal-title":"J Clin Dermatol Ther"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/19390211.2019.1619009"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155500750012487"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00307.x"},{"issue":"6","key":"e_1_2_9_19_1","first-page":"309","article-title":"Evaluation on azathioprine in the treatment of Parthenium dermatitis","volume":"67","author":"Khurana S","year":"2001","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13697"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.44299"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.440505.x"},{"issue":"3","key":"e_1_2_9_23_1","first-page":"129","article-title":"Failure of pentoxifylline to affect air\u2010borne contact dermatitis caused by parthenium","volume":"66","author":"Verma KK","year":"2000","journal-title":"Indian J Dermatol Venereol Leprol"},{"issue":"2","key":"e_1_2_9_24_1","first-page":"5","article-title":"Comparative study of weekly pulse doses of azathioprine versus weekly pulse doses of prednisolone in Parthenium dermatitis","volume":"8","author":"Rather PA","year":"2012","journal-title":"Egypt Dermatol Online J"},{"issue":"3","key":"e_1_2_9_25_1","first-page":"180","article-title":"A comparative study on the efficacy of methotrexate versus azathioprine for the treatment of airborne contact dermatitis due to parthenium","volume":"22","author":"Puri N","year":"2011","journal-title":"Dermatitis"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-6691.140780"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T08:56:37Z","timestamp":1696409797000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.14406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,27]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/cod.14406"],"URL":"https:\/\/doi.org\/10.1111\/cod.14406","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,27]]},"assertion":[{"value":"2023-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}