{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:09:27Z","timestamp":1771502967596,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:00:00Z","timestamp":1693353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006196","name":"Oulun Yliopisto","doi-asserted-by":"publisher","award":["24000692"],"award-info":[{"award-number":["24000692"]}],"id":[{"id":"10.13039\/501100006196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hand eczema (HE) is a common dermatological disorder with considerable effect on the health\u2010related quality of life (HRQoL). The data on mental comorbidities of HE is sparse and mostly studied among selected patient groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to investigate symptoms of depression and anxiety in patients with HE in general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Study subjects (<jats:italic>n<\/jats:italic>\u2009=\u20096695) belonging to the Northern Finland Birth Cohort 1966 Study (NFBC1966) responded to an extensive health questionnaire including questions about HE. Depression and anxiety symptoms were evaluated according to the Hopkins Symptom Checklist\u201025 (HSCL\u201025).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Having ever suffered from HE was reported by 853 (12.8%) study subjects. Symptoms scores of depression were significantly higher among (<jats:italic>n<\/jats:italic>\u2009=\u2009172, 20.3%) HE subjects compared with (<jats:italic>n<\/jats:italic>\u2009=\u2009884, 15.4%) subjects without HE (Odds ratio [OR] 1.40, 95% confidence interval [CI]: 1.17\u20131.68, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Correspondingly, symptoms scores of anxiety were also more common among (<jats:italic>n<\/jats:italic>\u2009=\u200990, 10.6%) HE subjects than among (<jats:italic>n<\/jats:italic>\u2009=\u2009448, 7.8%) subjects without HE (OR 1.40, 95% CI: 1.10\u20131.78, <jats:italic>P<\/jats:italic>\u2009=\u20090.007). In an adjusted model, the associations remained statistically significant (OR 1.30, 95% CI: 1.08\u20131.57, <jats:italic>P<\/jats:italic>\u2009=\u20090.007 and OR 1.34, 95% CI: 1.04\u20131.72, <jats:italic>P<\/jats:italic>\u2009=\u20090.021, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Symptoms associated with mental health should be taken into account when managing patients with HE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14412","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T22:55:07Z","timestamp":1693436107000},"page":"464-470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Anxiety and depression in patients with hand eczema: A population\u2010based study among 853 middle\u2010aged subjects"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1815-3754","authenticated-orcid":false,"given":"Marjut","family":"Koskelo","sequence":"first","affiliation":[{"name":"Department of Dermatology Oulu University Hospital  Oulu Finland"},{"name":"Medical Research Center, Research Unit of Clinical Medicine University of Oulu  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6496-5475","authenticated-orcid":false,"given":"Suvi\u2010P\u00e4ivikki","family":"Sinikumpu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oulu University Hospital  Oulu Finland"},{"name":"Medical Research Center, Research Unit of Clinical Medicine University of Oulu  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jari","family":"Jokelainen","sequence":"additional","affiliation":[{"name":"Northern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population Studies, Faculty of Medicine University of Oulu  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Huilaja","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oulu University Hospital  Oulu Finland"},{"name":"Medical Research Center, Research Unit of Clinical Medicine University of Oulu  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13804"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/COD.14205"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01669.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16147"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1104084"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/SJ.JID.5700781"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16061"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2009.09099.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/JDV.13479"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2006.00783.x"},{"key":"e_1_2_11_12_1","volume-title":"Hand Eczema Severity and Quality of Life: A Cross\u2010Sectional, Multicentre Study of Eczema Patients","author":"Agner T","year":"2008"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.0022\u2010202X.2004.22604.X"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.2012.02062.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/COD.12366"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/COD.12973"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyab109"},{"key":"e_1_2_11_18_1","unstructured":"University of Oulu.University of Oulu: Northern Finland Birth Cohort; 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