{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:26:00Z","timestamp":1777379160489,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Topical corticosteroids under occlusion have been used to enhance the treatment of eczema. However, no study has investigated the efficacy of a steroid\u2010containing transdermal patch for the treatment of chronic hand eczema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a randomized, controlled, assessor\u2010blinded trial to determine the efficacy of a transdermal patch containing betamethasone dipropionate compared to topical betamethasone dipropionate ointment in the treatment of mild to moderate chronic hand eczema. The patients were included and assigned to receive either the transdermal patch once daily at night or the ointment twice daily for a period of 8\u2009weeks. The outcomes were assessed using the Hand Eczema Severity Index (HECSI), Physical Global Assessment (PGA) score, self\u2010reported compliance, level of patient satisfaction, quality of life, and side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010six patients completed this study. At 8\u2009weeks, there was a significant reduction in the HECSI scores in both the transdermal patch and topical ointment groups compared to those measured at baseline (14.61 to 1.86, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; 18.46 to 3.43, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively) without a statistically significant difference between the two groups. Similarly, the two groups did not show any significant difference in the PGA scores, quality of life and side effects. However, the transdermal patch group reported better compliance and a higher level of patient satisfaction than the topical ointment group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The transdermal corticosteroid patch has proven to be a safe and effective treatment, comparable to topical corticosteroids, after 8\u2009weeks of use. Its sustained\u2010release properties, along with once\u2010daily use, can improve patient satisfaction and promote greater adherence to the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>This study was registered with the Thai Clinical Trials Registry (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.in.th\">www.clinicaltrials.in.th<\/jats:ext-link>) under registration number TCTR20220413003.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14438","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T03:25:40Z","timestamp":1697167540000},"page":"153-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The efficacy of a transdermal hydrogel patch containing betamethasone dipropionate for treatment of chronic hand eczema: A single\u2010blind, randomized and controlled trial"],"prefix":"10.1111","volume":"90","author":[{"given":"Sirinan","family":"Thaitirarot","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Srinakharinwirot University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duangratana","family":"Shuwisitkul","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Srinakharinwirot University  Ongkharak Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montree","family":"Udompataikul","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Srinakharinwirot University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanticha","family":"Kamanamool","sequence":"additional","affiliation":[{"name":"Department of Preventive and Social Medicine Srinakharinwirot University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-2725","authenticated-orcid":false,"given":"Silada","family":"Kanokrungsee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Srinakharinwirot University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14035"},{"issue":"4","key":"e_1_2_11_3_1","article-title":"Interventions for hand eczema","volume":"4","author":"Christoffers WA","year":"2019","journal-title":"Cochrane Database Syst 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hormone therapy in postmenopausal women: a review of metabolic effects and drug delivery technologies","volume":"2","author":"Kopper NW","year":"2009","journal-title":"Drug Des Devel Ther"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-973X.76721"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00276-002-0034-5"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0073"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics10020071"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.139874"},{"issue":"10","key":"e_1_2_11_27_1","first-page":"1182","article-title":"Percutaneous absorption","volume":"110","author":"Brisson P","year":"1974","journal-title":"Can Med Assoc J"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.01.010"},{"key":"e_1_2_11_29_1","unstructured":"National Center for Biotechnology Information. 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Accessed October 11 2023.https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Betamethasone\u2010dipropionate."}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T01:18:54Z","timestamp":1705713534000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.14438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,12]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/cod.14438"],"URL":"https:\/\/doi.org\/10.1111\/cod.14438","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,12]]},"assertion":[{"value":"2023-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}