{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:53:30Z","timestamp":1791870810525,"version":"4.3.4"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>During the last 15\u201320\u2009years, allergic contact dermatitis from acrylates\u2010containing nail cosmetics (acrylic nails, gel nails, gel nail polish) has been increasingly reported. 2\u2010Hydroxyethyl methacrylate (HEMA) is considered to be the major allergenic culprit; few data on its presence in nail cosmetics are available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate (1) the frequency in which HEMA and di\u2010HEMA trimethylhexyl dicarbamate are present in nail cosmetics; (2) whether nail cosmetics comply with EU regulations; (3) which other (meth)acrylates are present in nail cosmetics and how often.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One\u2010line market survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HEMA was present in nearly 60% of 394 cosmetic nail products and di\u2010HEMA trimethylhexyl dicarbamate in 34%. Mandatory warnings on the packages of products containing HEMA were absent in 35% (\u2018For professional use only\u2019) resp. 55% (\u2018Can cause an allergic reaction\u2019). Forty\u2010five other (meth)acrylates were identified, of which the most frequent were hydroxypropyl methacrylate (25%), isobornyl methacrylate (16%) and trimethylolpropane triacrylate (12%). Some ingredient lists mentioned non\u2010INCI names or non\u2010specific names.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HEMA was by far the most common ingredient of nail cosmetics, being present in nearly 60% of the products. Violations of EU legislation occurred in &gt;30% (mandatory warnings missing) resp. 10% (mislabelling) of nail cosmetics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14441","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T23:52:04Z","timestamp":1697586724000},"page":"60-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Presence of 2\u2010hydroxyethyl methacrylate (<scp>HEMA<\/scp>) and other (meth)acrylates in nail cosmetics, and compliance with <scp>EU<\/scp> legislation: An online market survey"],"prefix":"10.1111","volume":"90","author":[{"given":"Iemke M.","family":"Steunebrink","sequence":"first","affiliation":[{"name":"Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6666-7292","authenticated-orcid":false,"given":"Anton","family":"de Groot","sequence":"additional","affiliation":[{"name":"Dermato\u2010Allergology and Occupational Dermatology Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7580-0684","authenticated-orcid":false,"given":"Thomas","family":"Rustemeyer","sequence":"additional","affiliation":[{"name":"Dermato\u2010Allergology and Occupational Dermatology Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14405"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14430"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12948"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12827"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105\u20101873.2005.00496.x"},{"key":"e_1_2_8_7_1","unstructured":"Netherlands Food and Consumers Product Safety Authority.Nagelverfraaiing. Gelnagelproducten acrylvloeistoffen en primers.https:\/\/www.nvwa.nl\/documenten\/consument\/consumentenartikelen\/non\u2010food\/cosmetica\/rapportage\u2010uitkomsten\u2010marktonderzoek\u2010nagelproducten. Accessed August 22 2023"},{"key":"e_1_2_8_8_1","unstructured":"Commission regulation (EU) 2020\/1682 of November 12 2020 amending annex III to regulation (EC) No 1223\/2009 of the European Parliament and of the council on cosmetic products.2020Official J Eur Union. 379:31\u201333. DESK EDITOR: this journal has no issue numbers."}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T02:12:04Z","timestamp":1703729524000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.14441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,17]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/cod.14441"],"URL":"https:\/\/doi.org\/10.1111\/cod.14441","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,17]]},"assertion":[{"value":"2023-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}