{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:51:14Z","timestamp":1778201474303,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcriptome analyses of vesicular hand eczema (VHE) indicated a large overlap with atopic dermatitis (AD). However, differentially expressed genes (DEGs) that differentiate VHE from AD are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify distinctive transcriptional features of VHE in comparison to AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We re\u2010analysed RNA sequencing data of 10 lesional palmar VHE epidermal biopsies and performed DEG analyses. We adjusted the obtained DEG results of 57 lesional whole AD skin biopsies of the upper extremities or trunk to our criteria. Up\u2010 and down\u2010regulated DEGs in both skin diseases, VHE\u2010only, AD\u2010only, and opposite regulated DEGs were identified. Enrichment analyses and Chi\u2010squared tests were conducted to test for differences in gene set enrichment between both skin diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparing 3028 DEGs in VHE (1645 up; 1383 down) with 5391 DEGs in AD (3842 up; 1549 down), revealed 1516 shared DEGs (1179 up; 337 down) and 1512 DEGs unique to VHE (466 up, 1046 down). Interferon signalling and necroptosis were significantly more prominent in VHE compared to AD. Downregulated genes identified only in VHE (like <jats:italic>DNASE1L2, KRT2, KRT9<\/jats:italic> and <jats:italic>KRT25)<\/jats:italic> indicate an aberrant epidermal differentiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study indicates a common pathophysiology between VHE and AD, but also reveals transcriptional differences between VHE and AD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14442","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T02:33:28Z","timestamp":1697769208000},"page":"23-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Transcriptional differences between vesicular hand eczema and atopic dermatitis"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6499-2684","authenticated-orcid":false,"given":"Fieke M.","family":"Rosenberg","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9891-1897","authenticated-orcid":false,"given":"Ren\u00e9","family":"Wardenaar","sequence":"additional","affiliation":[{"name":"European Research Institute for the Biology of Ageing (ERIBA) University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5061-894X","authenticated-orcid":false,"given":"Angelique N.","family":"Voorberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8403-474X","authenticated-orcid":false,"given":"Diana C. 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