{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:15:21Z","timestamp":1788581721097,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Contact allergy to the mint\u2010tasting flavour carvone has been observed in patients with oral lichenoid lesions (OLL). Mint\u2010flavoured products such as toothpaste frequently contain carvone. Snuff is a smokeless tobacco product that is chewed or placed in the mouth rather than smoked. In Sweden, the use of snuff and its flavoured versions is extremely common.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate whether the consumption of mint\u2010flavoured snuff is associated with contact allergy to carvone and subsequently plays a role in the aetiology of OLL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Regarding the two patients, patch testing with snuff pouches was performed. High\u2010performance liquid chromatography and gas chromatography\u2013mass spectrometry analysis were used for identification of carvone in different snuff samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two patients with OLL were contacted allergic to carvone when patch tested. Both were using mint\u2010flavoured snuffs several hours a day for many years. One patient was contacted allergic to the snuff pouch tested as is. Carvone was detected in the snuff samples of both patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The patients were recommended to avoid the use of mint\u2010flavoured snuffs, toothpaste and foodstuffs. At follow\u2010up 3\u2009months later, the patients had a dramatic clinical improvement of the OLL and oral symptoms. Exposure to mint\u2010flavoured snuffs can be overlooked as a possible aggravating\/provoking factor in OLL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14448","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T05:45:39Z","timestamp":1698903939000},"page":"74-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Oral lichenoid lesions in two snuff users with contact allergy to carvone"],"prefix":"10.1111","volume":"90","author":[{"given":"Usamah","family":"Adwa","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital  Malmo Sweden"},{"name":"Department of Dermatology Helsingborg Hospital  Helsingborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5067-2564","authenticated-orcid":false,"given":"Annarita","family":"Antelmi","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital  Malmo Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5351-2988","authenticated-orcid":false,"given":"Thanisorn","family":"Sukakul","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital  Malmo Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1058-1959","authenticated-orcid":false,"given":"Jakob","family":"Dahlin","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital  Malmo Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-3227","authenticated-orcid":false,"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital  Malmo Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Svedman","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital  Malmo Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2012.00908.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12803"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14249"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14302"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckw032"},{"key":"e_1_2_8_8_1","unstructured":"Health Effects of Smokeless Tobacco Products.Scientific Committee on Emerging and Newly Identified Health Risks.http:\/\/ec.europa.eu\/health\/ph_risk\/committees\/04_scenihr\/docs\/scenihr_o_013.pdf"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4045\/tidskr.19.0746"},{"key":"e_1_2_8_10_1","volume-title":"Manual of Contact Dermatitis","author":"Fregert S","year":"1981"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60678-3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.18001\/TRS.3.3.12"},{"key":"e_1_2_8_14_1","unstructured":"KroonaL.Oral Contact Allergy to Carvone. With a Focus on Oral Lichen. Doctoral Thesis. Malm\u00f6 University.2018."},{"key":"e_1_2_8_15_1","unstructured":"International Fragrance Association (IFRA).IFRA Standards 50th Amedment l\u2010carvone.2022www.ifraorg.org"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T02:11:21Z","timestamp":1703729481000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.14448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/cod.14448"],"URL":"https:\/\/doi.org\/10.1111\/cod.14448","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"2023-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}