{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T10:31:21Z","timestamp":1777285881180,"version":"3.51.4"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ethylenediamine dihydrochloride is a versatile aliphatic amine found in numerous medications and industrial compounds and is a known sensitiser. The sensitization prevalence is affected by geographical and socio\u2010cultural factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objectives are to analyse the temporal trend of sensitization to ethylenediamine dihydrochloride in northeastern Italy and to investigate associations with occupations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 1996 and 2021, 30\u2009629 patients with suspected allergic contact dermatitis were patch tested with the Triveneto baseline series. Individual characteristics were collected through a standardised questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall prevalence of ethylenediamine dihydrochloride sensitization was 1.29% with percentages similar in both sexes. We observed a significant decreasing trend over time (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), yielding a sensitization prevalence &lt;1% in recent years. Among departments, residence in Pordenone area was protective for sensitization. No significant associations were observed with specific occupations. We found significant associations between ethylenediamine dihydrochloride sensitization and being 26\u201335\u2009years old (odds ratio [OR], 1.47; 95% confidence interval [CI]: 1.05\u20132.08), and sensitization for many haptens, such as paraben mix (OR, 5.3; 95% CI: 3.3\u20138.5), epoxy resin (OR, 5.1; 95% CI: 3.0\u20138.7), neomycin sulphate and mercaptobenzothiazole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study showed a downward time trend of ethylenediamine dihydrochloride sensitization in northeastern Italian population and pointed to an update of the Triveneto baseline series.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14454","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T13:57:33Z","timestamp":1701439053000},"page":"253-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sensitization to ethylenediamine dihydrochloride in patients with contact dermatitis in northeastern <scp>Italy<\/scp> from 1996 to 2021"],"prefix":"10.1111","volume":"90","author":[{"given":"Linda","family":"Piapan","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Clinical Unit of Occupational Medicine University of Trieste  Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5791-0775","authenticated-orcid":false,"given":"Anna","family":"Belloni Fortina","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dermatology Unit University of Padua  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Giulioni","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Ospedale Santa Maria degli Angeli Azienda Sanitaria Friuli Orientale  Pordenone Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7717-0417","authenticated-orcid":false,"given":"Francesca","family":"Larese Filon","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Clinical Unit of Occupational Medicine University of Trieste  Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"National Center for Biotechnology Information.PubChem compound summary for CID 9521 ethylenediamine dihydrochloride. Accessed August 16 2023.https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Ethylenediamine-dihydrochloride"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1984.tb00937.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.03.006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02097249"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770909009073328"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13676"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1958.tb04018.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1959.01560180021006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1987.tb02731.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1994.tb02035.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1967.01610030009002"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.98.5.476"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190\u20109622(89)80009\u2010x"},{"issue":"4","key":"e_1_2_9_15_1","first-page":"241","article-title":"The significance of ethylenediamine hydrochloride dermatitis caused by a \u201cgeneric\u201d nystatin\u2010triamcinolone II cream","volume":"41","author":"Fisher AA","year":"1988","journal-title":"Cutis"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190\u20109622(88)80145\u20102"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30536-9"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0196\u20100644(05)80895\u20109"},{"key":"e_1_2_9_19_1","first-page":"453","volume-title":"Allergens from the Standard Series","author":"Andersen KE","year":"2006"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1995.tb00519.x"},{"key":"e_1_2_9_21_1","unstructured":"Contact Dermatitis Institute.Allergen database ethylenediamine dihydrochloride. Accessed August 16 2023.https:\/\/www.contactdermatitisinstitute.com\/ethylenediamine-dihydrochloride.php"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1998.tb05782.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1977.tb03662.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1978.tb03850.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1997.tb00278.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1993.tb04535.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1989.tb04660.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1994.tb00584.x"},{"issue":"5","key":"e_1_2_9_29_1","first-page":"839","article-title":"Cross\u2010reactions between epoxy resin \u201camine\u201d hardeners and ethylenediamine","volume":"17","author":"Fisher AA","year":"1976","journal-title":"Cutis"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1975.tb05471.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1995.tb00534.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2007.2"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13687"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13089"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13512"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"issue":"4","key":"e_1_2_9_37_1","first-page":"287","article-title":"Terminology of contact dermatitis","volume":"50","author":"Wilkinson D","year":"1970","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2016.04.009"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14170"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1991.tb01867.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1985.tb01133.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1980.tb04954.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13704"},{"key":"e_1_2_9_44_1","unstructured":"Chemotechnique Diagnostics.The patch tester\u2014The European baseline vs. True test edition. Edition #14 March 2023. Accessed September 8 2023.http:\/\/www.patchtester.com\/wp-content\/uploads\/2023\/03\/The-Patch-Tester-issue-14-pages-FINAL.pdf"},{"key":"e_1_2_9_45_1","unstructured":"European Chemicals Agency (ECHA).Annex XV report. Support document\u2014ethylenediamine. Accessed September 8 2023.https:\/\/echa.europa.eu\/documents\/10162\/f0a61fa4\u201064d1\u20102d19\u201035ed\u2010d98134aec10d"},{"key":"e_1_2_9_46_1","unstructured":"Regione Emilia\u2010Romagna.Innovazione sanitaria e sociale. Dossier n. 44\/2000\u2014L'Osservatorio per le dermatiti professionali della provincia di Bologna\u2014Innovazione sanitaria e sociale (regione.emilia\u2010romagna.it). Accessed September 8 2023."},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000450"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2019.86709"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13970"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12661"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8706-z"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16248"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/21556660.2019.1619570"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12385"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13137"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.5070\/D36RD716H9"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2022.02.003"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100536.2000.042001011.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T16:22:50Z","timestamp":1707754970000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.14454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/cod.14454"],"URL":"https:\/\/doi.org\/10.1111\/cod.14454","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"2023-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}