{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:24:04Z","timestamp":1783427044300,"version":"3.54.6"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is speculation that some environmental factors may be impacting the increasing incidence of frontal fibrosing alopecia (FFA). In a recent publication, sensitisation to benzyl salicylate was shown to be prevalent among 36 patients with FFA. Ethylhexyl salicylate (EHS), a light stabiliser, ultraviolet (UV) B absorber and UV filter, frequently found in photoprotectors\/cosmetics and, rarely reported as a sensitiser, was not patch tested in said research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 2021 to February 2022, 33 patients with FFA were patch\u2010tested with the European Photopatch Series, including EHS 10% pet. in two hospitals. In addition, we conducted a literature review and a market survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patch test reactions to EHS were identified in 9 of 33 (27.3%). Four of nine also reacted to their personal sunscreens (containing EHS). All involved women with a mean age of 54 (30\u201365). Five patients had been diagnosed with FFA before the patch tests; and, four were diagnosed with FFA during the patch test investigations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sensitisation to EHS was frequently found in a selected population of patients with FFA. We propose to expand the spectrum of contact allergens described in patients with FFA to include EHS and discuss the possible need for optimization of the patch test preparation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14463","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:40:16Z","timestamp":1701132016000},"page":"402-410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sensitisation to ethylhexyl salicylate: Another piece of the frontal fibrosing alopecia puzzle"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8382-5419","authenticated-orcid":false,"given":"Mar\u00eda Antonia","family":"Pastor\u2010Nieto","sequence":"first","affiliation":[{"name":"Dermatology Department Hospital Universitario de Guadalajara  Guadalajara Spain"},{"name":"Dermatology Department Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid Spain"},{"name":"Medicine and Medical Specialties Department Faculty of Medicine and Health Sciences, Universidad de Alcal\u00e1  Alcal\u00e1 de Henares Spain"},{"name":"Universidad de Castilla\u2010La\u2010Mancha  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8203-5834","authenticated-orcid":false,"given":"Mar\u00eda Elena","family":"Gatica\u2010Ortega","sequence":"additional","affiliation":[{"name":"Universidad de Castilla\u2010La\u2010Mancha  Toledo Spain"},{"name":"Dermatology Department Complejo Hospitalario Universitario de Toledo  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0199-2756","authenticated-orcid":false,"given":"Leopoldo","family":"Borrego","sequence":"additional","affiliation":[{"name":"Dermatology Department Universidad de Las Palmas de Gran Canaria, Hospital Universitario Insular  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10091805"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14535"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13785"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17354"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16933"},{"key":"e_1_2_8_7_1","article-title":"Allergic contact dermatitis in patients with frontal fibrosing alopecia: an international multi\u2010center study","volume":"12","author":"Rudnicka L","year":"2020","journal-title":"Dermatol Ther"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.01.026"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13763"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13939"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14053"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14061"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14139"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14370"},{"key":"e_1_2_8_15_1","unstructured":"2\u2010Ethylhexyl salicylate Pub Chem compound summary. Accessed September 7 2023.https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/2-Ethylhexyl-salicylate"},{"key":"e_1_2_8_16_1","unstructured":"CosIng European Commission database for information on cosmetic substances and ingredients. Accessed September 7 2023.https:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/details\/33893"},{"key":"e_1_2_8_17_1","unstructured":"2\u2010Ethylhexyl salicylate. European Chemical Agency (ECHA) Substance Infocard. Accessed September 7 2023.https:\/\/echa.europa.eu\/es\/substance-information\/-\/substanceinfo\/100.003.877"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13308"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12037"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_8_21_1","volume-title":"Vademecum Dermatolog\u00eda Cosm\u00e9tica 2020","year":"2019"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01634989-200306000-00005"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2006.05046"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.00942.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2010.09090"},{"issue":"1","key":"e_1_2_8_26_1","first-page":"66","article-title":"Allergic contact dermatitis from ethylhexyl salicylate","volume":"25","author":"Miralles JC","year":"2015","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000300"},{"key":"e_1_2_8_28_1","unstructured":"Cosmetic Products Regulation Annex VI\u2010Allowed UV Filters. Accessed September 7 2023.https:\/\/echa.europa.eu\/es\/cosmetics\u2010uv\u2010filters?p_p_id=eucleflegislationlist_WAR_euclefportlet&p_p_lifecycle=0"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2006.05017"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2019.02.014"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2019.04.001"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-019-02537-z"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12245"},{"key":"e_1_2_8_34_1","first-page":"195","article-title":"Allergy to sunscreens","volume":"31","author":"Mancel E","year":"1999","journal-title":"Allerg Immunol (Paris)"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13974"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15576"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1978.01640150078023"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00614_2.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199106000-00018"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.114593"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000490362"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.5070\/D32611047744"},{"key":"e_1_2_8_43_1","unstructured":"Hydroxybenzoates. National Library of Medicine. Accessed September 7 2023.https:\/\/www.ncbi.nlm.nih.gov\/mesh\/68062385"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-023-02604-7"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T02:07:02Z","timestamp":1718676422000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.14463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,27]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/cod.14463"],"URL":"https:\/\/doi.org\/10.1111\/cod.14463","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,27]]},"assertion":[{"value":"2023-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}