{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:35:23Z","timestamp":1790879723438,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A global epidemic of allergic contact dermatitis to (meth)acrylates has been described in relation to the widespread use of manicure products.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the frequency of sensitization to 2\u2010hydroxyethyl methacrylate (2\u2010HEMA) among consecutively patch tested patients with eczema in Spain; the percentage of current relevance; the MOAHLFA index; and, the potential sources of exposure to (meth)acrylates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 2019 to December 2022, 2\u2010HEMA 2% pet. was prospectively patch tested in 24 REIDAC (Spanish Allergic Contact Dermatitis Registry) centres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six thousand one hundred thirty\u2010four patients were consecutively patch tested with 2\u2010HEMA 2% pet. 265\/6134 (4.3%) were positive. Positive reactions of current relevance were identified to involve 184\/265 (69%). The efficiency (number of patch tests needed to detect relevant positive patch test reactions) was 34 (6134\/184). The variable \u2018occupational\u2019 was found to be significantly associated with a higher risk for relevant positive reactions to 2\u2010HEMA (OR: 10.9; 95% CI: 8.1\u201314.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>(Meth)acrylate sensitization is a prevalent health issue in Spain. 2\u2010HEMA 2% pet. has been identified to be a highly effective (meth)acrylate allergy marker in the GEIDAC baseline series. The responsible authorities should implement policies guaranteeing accurate labelling of industrial, medical, and consumer materials while ensuring the enforcement of said labelling through appropriate legal means.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14520","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T04:34:03Z","timestamp":1707885243000},"page":"507-513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<scp>2\u2010Hydroxyethyl<\/scp> methacrylate (<scp>2\u2010HEMA<\/scp>) sensitization, a global epidemic at its peak in Spain?"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8203-5834","authenticated-orcid":false,"given":"Maria Elena","family":"Gatica\u2010Ortega","sequence":"first","affiliation":[{"name":"Dermatology Department Complejo Hospitalario Universitario de Toledo  Toledo Spain"},{"name":"Escuela Internacional de Doctorado Universidad de Castilla\u2010La\u2010Mancha  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Antonia","family":"Pastor\u2010Nieto","sequence":"additional","affiliation":[{"name":"Escuela Internacional de Doctorado Universidad de Castilla\u2010La\u2010Mancha  Toledo Spain"},{"name":"Dermatology Department Hospital Universitario de Guadalajara  Guadalajara Spain"},{"name":"Dermatology Department Hospital Universitario Fundacion Jim\u00e9nez D\u00edaz  Madrid Spain"},{"name":"Faculty of Medicine and Health Sciences, Medicine and Medical Specialties Department Universidad de Alcal\u00e1  Alcal\u00e1 de Henares Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5434-7753","authenticated-orcid":false,"given":"Ana Mar\u00eda","family":"Gim\u00e9nez\u2010Arnau","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital del Mar Research Institute Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8309-9725","authenticated-orcid":false,"given":"Pedro","family":"Mercader\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital General Universitario Jos\u00e9 M\u00aa Morales Meseguer  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5796-7680","authenticated-orcid":false,"given":"Tatiana","family":"Sanz\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Universitario Infanta Sof\u00eda  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Carrascosa\u2010Carrillo","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Universitari Germans Trias i Pujol, IGTP, UAB  Barcelona 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Universitario 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3904-3396","authenticated-orcid":false,"given":"F\u00e1tima","family":"Tous\u2010Romero","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Universitario 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Fern\u00e1ndez\u2010Redondo","sequence":"additional","affiliation":[{"name":"Dermatology Department Complejo Hospitalario Universitario  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Serra\u2010Baldrich","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital de La Santa Creu i Sant Pau  Barcelona 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\u00c1ngel","family":"Descalzo","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n of the Fundaci\u00f3n Piel Sana AEDV of the Spanish Academy of Dermatology  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"de\u2010Vega","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n of the Fundaci\u00f3n Piel Sana AEDV of the Spanish Academy of Dermatology  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Garc\u00eda\u2010Doval","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n of the Fundaci\u00f3n Piel Sana AEDV of the Spanish Academy of Dermatology  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0199-2756","authenticated-orcid":false,"given":"Leopoldo","family":"Borrego","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital 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June 2018. SCCS\/1592\/17.2018Accessed Jun 29 2023.https:\/\/health.ec.europa.eu\/system\/files\/2021-08sccs_o_214_0.pdf"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40521\u2010020\u201000272\u2010w"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14263244"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14288"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13698"},{"issue":"3","key":"e_1_2_8_29_1","first-page":"143","article-title":"Contact dermatitis to incontinency pads in a (meth)acrylate allergic patient","volume":"13","author":"Giroux L","year":"2002","journal-title":"Am J Contact Dermat"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000136"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/JW9.0000000000000077"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14408"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T12:57:46Z","timestamp":1712321866000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.14520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,13]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/cod.14520"],"URL":"https:\/\/doi.org\/10.1111\/cod.14520","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,13]]},"assertion":[{"value":"2023-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}