{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T10:30:56Z","timestamp":1777285856860,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T00:00:00Z","timestamp":1708214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The baseline series includes common allergens, evolves over time, and differs by location. Our study aims to characterize allergen sensitization trends among the Israeli population during the last two decades, compare our results to American and European registries, as well as to highlight significant allergens in additional series outside the European baseline series (OEBS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed patch test results of 2086 patients from a designated contact dermatitis clinic in Tel Aviv between 2019 and 2022, compared them to European and North American registries and to 2156 patch test results conducted in Israel two decades ago.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>38.6% of patients had at least one positive reaction to an allergen in the European baseline series (EBS), nickel sulphate (14.6%), fragrance mix I (4.6%), and Methylchloroisothiazolinone methylisothiazolinone (MCI\/MI; 3.7%) were the most common among them. N\u2010Isopropyl N\u2010Phenyl\u20104\u2010Phenylenediamine (NIPPD; 0%), Propolis (0.1%), Sesquiterpene lactone mix (0.1%), and Budesonide (0.1%) elicited a sensitization frequency significantly lower than the proposed threshold for baseline inclusion. Chi\u2010square test revealed a statistically significant decrease (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) in the sensitization frequency of fragrance mix I, Formaldehyde, Potassium dichromate, Neomycin sulphate, Myroxylon pereirae, Sesquiterpene lactone, and NIPPD during the last two decades. The overall sensitization frequency to the majority of allergens was lower in our cohort in comparison to the North American and European registries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MCI\/MI and 2\u2010hydroxyethyl methacrylate\u20102 (HEMA) are common, relevant allergens, with high SPIN (significance and prevalence index number) and should be better regulated by the authorities. While among the EBS, NIPPD, Propolis, Sesquiterpene lactone, and Budesonide usually do not elicit a positive reaction and therefore should be reconsidered in baseline series, among the OEBS, Chloramphenicol, Quaternium 15, Propyl gallate, and Amerchol L101 have elicited high SPIN values and should be vigilantly examined in the suitable clinical scenario. Significantly lower sensitization frequency to propolis raises the possibility of a protective effect due to early oral exposure among the Israeli population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14524","type":"journal-article","created":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T22:03:31Z","timestamp":1708293811000},"page":"556-565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Trends in contact sensitization, results, and implications from a contact dermatitis clinic in <scp>Israel<\/scp>"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6560-2625","authenticated-orcid":false,"given":"Dan","family":"Slodownik","sequence":"first","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Department of Dermatology Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Bar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Department of Dermatology Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danny","family":"Daniely","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Department of Dermatology Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12362"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2006.00875.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13836"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2016.04.005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1999.tb06154.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13155"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_8_9_1","unstructured":"Patch Testing: Test Concentrations and Vehicles for 4900 Chemicals. 4th ed \u2013 Search Results \u2013 PubMed [Internet]. Accessed January 2 2023. Available from:https:\/\/vpn\u2010lib.tasmc.org.il\/f5\u2010w\u201068747470733a2f2f7075626d65642e6e6362692e6e6c6d2e6e69682e676f76$$\/?term=+Patch+Testing%3A+Test+Concentrations+and+Vehicles+for+4900+Chemicals.+4th+ed"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13704"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14170"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000729"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14059"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.03.028"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.02.1139"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01824.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.05.047"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000558"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14300"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2022.29017.jdk"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v101.423"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.01066.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.08.039"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2023.0085"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01292.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.07.030"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12302-020-00377-8"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13970"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2011-100220"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14089"},{"issue":"4","key":"e_1_2_8_31_1","first-page":"573","article-title":"Significance\u2010prevalence index number: a reinterpretation and enhancement of data from the north American contact dermatitis group","volume":"41","author":"Maouad M","year":"1999","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12556"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000948"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.5991"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.10.032"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01364.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13837"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000373"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01705.x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14241"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01631.x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113473"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1994.tb01959.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02135.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01150.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000263"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12591"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13210"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12952"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000889"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14524","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T01:32:22Z","timestamp":1714699942000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.14524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,18]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/cod.14524"],"URL":"https:\/\/doi.org\/10.1111\/cod.14524","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,18]]},"assertion":[{"value":"2023-08-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}