{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:51:04Z","timestamp":1770814264794,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Quantitative risk assessment (QRA) for skin sensitization is used to derive safe use levels of sensitising fragrance ingredients in products. Post\u2010marketing surveillance of the prevalence of contact allergy to these ingredients provides relevant data to help evaluate the performance of these measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine a suitable patch test concentration for five fragrance materials that had hitherto not been tested on a regular basis. These concentrations are then to be used in a surveillance study with patch testing consecutive patients over an extended monitoring period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Furaneol, CAS.3658\u201077\u20103; trans\u20102\u2010hexenal, CAS.6728\u201026\u20103; 4,8\u2010dimethyl\u20104,9\u2010decadienal, CAS.71077\u201031\u20101; longifolene, CAS.475\u201020\u20107; benzaldehyde, CAS.10052\u20107, were patch tested with other fragrance allergens in four clinics. Patch testing was conducted in three rounds, starting with the lowest concentrations of the five ingredients. The doses were increased in the subsequent rounds if no late\u2010appearing positive reactions and virtually no irritant reactions were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 373 patients were tested. No positive allergic reaction was reported to the five ingredients. Patch test results of other fragrance allergens are reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The highest test concentrations are each considered safe for patch testing consecutive patients. Further surveillance based on these preparations will evaluate the hypothesis that QRA\u2010driven consumer product levels of these fragrances can prevent sensitization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14525","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T22:05:30Z","timestamp":1708639530000},"page":"566-573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Results of patch testing with five fragrance materials hitherto not tested: A dose\u2010finding study in the clinical population"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5351-2988","authenticated-orcid":false,"given":"Thanisorn","family":"Sukakul","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Dermatology, Faculty of Medicine Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4498-3710","authenticated-orcid":false,"given":"Wolfgang","family":"Uter","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Biometry and Epidemiology University of Erlangen\/N\u00fcrnberg  Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6842-1360","authenticated-orcid":false,"given":"Margarida","family":"Gon\u00e7alo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Coimbra University Hospital and Faculty of Medicine University of Coimbra  Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Huggard","sequence":"additional","affiliation":[{"name":"The Huggard Consulting Group, S.A.R.L.  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