{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:50:56Z","timestamp":1791809456621,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002706","name":"AFA F\u00f6rs\u00e4kring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005390","name":"Alfred \u00d6sterlunds Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005390","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008245","name":"Edvard Welanders Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Allergic contact dermatitis (ACD) from rubber glove usage is usually caused by rubber additives such as the accelerators. However, in analyses of the suspected gloves, ordinary rubber allergens are not always found. Accelerator\u2010free rubber gloves are available, but some patients with accelerator allergy do not tolerate them and might also be patch test positive to them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify and chemically characterize a new allergen, 2\u2010cyanoethyl dimethyldithiocarbamate (CEDMC), in rubber gloves. We describe two patient cases: patient 1 that led us to the identification of CEDMC and patient 2 with occupational ACD caused by CEDMC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The patients were examined with patch testing including baseline and rubber series, and their own rubber gloves. High\u2010performance liquid chromatography (HPLC) was used for chemical analysis of rubber gloves. The allergen was synthesized and identified by nuclear magnetic resonance, mass spectrometry and infrared spectrometry, and tested on patient 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CEDMC was identified by HPLC in a nitrile glove associated with hand eczema in patient 1. Patient 2 whose nitrile gloves contained CEDMC was patch test positive to CEDMC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CEDMC is a new contact allergen in nitrile gloves and probably forms during vulcanization from residual monomer acrylonitrile and rubber additives.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14553","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T11:11:07Z","timestamp":1712833867000},"page":"45-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["2\u2010Cyanoethyl dimethyldithiocarbamate, a new contact allergen found in accelerator\u2010free nitrile gloves"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5401-2435","authenticated-orcid":false,"given":"Linda","family":"Ljungberg Silic","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Persson","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0356-7064","authenticated-orcid":false,"given":"Maria","family":"Pesonen","sequence":"additional","affiliation":[{"name":"Occupational Health Unit Finnish Institute of Occupational Health  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1353-121X","authenticated-orcid":false,"given":"Katri","family":"Suuronen","sequence":"additional","affiliation":[{"name":"Occupational Health Unit Finnish Institute of Occupational Health  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Svedman","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Bergendorff","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Lund University  Malm\u00f6 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