{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:38:37Z","timestamp":1783021117045,"version":"3.54.6"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Allergic contact dermatitis (ACD) to salicylic acid (SA) is widely unreported. Furthermore, cross\u2010reactivity between SA and other salicylates has not been reported despite well\u2010documented in\u2010group salicylate cross\u2010reactivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe our clinic's experience patch testing to SA, highlighting seven cases of relevant reactions and concomitant reactivity with other salicylates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Results of patch testing to 5% SA in petrolatum between 1 January 2020, and 9 February 2024, are reported. Seven cases of relevant reactions to SA are detailed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 489 patients (27.5%) were tested to SA, 21 of which were positive: 7 doubtful (+\/\u2212), 14 weak positive (+), and no strong\/extreme positive reactions. Four irritant reactions were documented. Of the 14 weak positive (+) reactions, 7 had definite or probable clinical relevance, 5 of which also reacted to other salicylates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ACD to SA is likely underreported due to a lack of testing. In our experience, testing SA 5% petrolatum is tolerable without significant irritation. Cross\u2010reactivity between SA and other salicylates is probable. Though SA appears to be the primary sensitizer in some cases, more studies are needed to understand its possible role as a marker for salicylate allergy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14573","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T10:38:51Z","timestamp":1714473531000},"page":"133-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Allergic contact dermatitis to salicylic acid: A case series of relevant sensitization"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9118-1849","authenticated-orcid":false,"given":"Caroline","family":"Brumley","sequence":"first","affiliation":[{"name":"Park Nicollet Contact Dermatitis Clinic, Department of Dermatology Park Nicollet Health Services\/HealthPartners  Minneapolis Minnesota USA"},{"name":"University of Minnesota Medical School  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8367-761X","authenticated-orcid":false,"given":"Puneet","family":"Arora","sequence":"additional","affiliation":[{"name":"Park Nicollet Contact Dermatitis Clinic, Department of Dermatology Park Nicollet Health Services\/HealthPartners  Minneapolis Minnesota USA"},{"name":"University of Minnesota Medical School  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Neeley","sequence":"additional","affiliation":[{"name":"Park Nicollet Contact Dermatitis Clinic, Department of Dermatology Park Nicollet Health Services\/HealthPartners  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Hylwa","sequence":"additional","affiliation":[{"name":"Park Nicollet Contact Dermatitis Clinic, Department of Dermatology Park Nicollet Health Services\/HealthPartners  Minneapolis Minnesota USA"},{"name":"Department of Dermatology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S84765"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2010.09090"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000963"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1986.tb01212.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1986.tb01173.x"},{"key":"e_1_2_10_7_1","unstructured":"European Commission Scientific Committee on Consumer Safety.Opinion on salicylic acid (CAS No. 69\u201072\u20107 EC No. 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contact dermatitis from ethylhexyl salicylate","volume":"25","author":"Miralles JC","year":"2015","journal-title":"J Invest Allergol Clin Immunol"}],"container-title":["Contact 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