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We performed a discovery genome\u2010wide association study (GWAS) of HE (2879 cases and 16\u2009249 controls) and of AD (1706 cases and 17\u2009190 controls). We replicated our findings in an independent Lifelines sample for HE (1188 cases and 6431 controls) and AD (757 cases and 6747 controls). We conducted several post\u2010GWAS analyses and performed genetic correlation analyses between our HE results and independent AD data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The two\u2010step GWAS of HE, regardless of adjusting for AD, identified one independent locus 20q13.33, likely driven by a number of causal single\u2010nucleotide polymorphisms. For the AD GWAS, we replicated a known stop\u2010gained rs61816761 at locus 1q21.3 (<jats:italic>FLG<\/jats:italic>, <jats:italic>FLGAS1<\/jats:italic>). We found a strong genetic correlation (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) between HE and AD (<jats:italic>r<\/jats:italic><jats:sub>g<\/jats:sub>\u2009=\u20090.65), regardless of adjusting for AD (<jats:italic>r<\/jats:italic><jats:sub>g<\/jats:sub>\u2009=\u20090.63).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Locus 20q13.33 is associated with HE, and there is a large genetic overlap between HE and AD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14619","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T07:10:38Z","timestamp":1719213038000},"page":"190-202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A genome\u2010wide association study of hand eczema identifies locus 20q13.33 and reveals genetic overlap with atopic dermatitis"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6499-2684","authenticated-orcid":false,"given":"Fieke M.","family":"Rosenberg","sequence":"first","affiliation":[{"name":"Department of Dermatology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8450-3518","authenticated-orcid":false,"given":"Peter J.","family":"van der Most","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2731-9284","authenticated-orcid":false,"given":"Laura","family":"Loman","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6492-5887","authenticated-orcid":false,"given":"Zoha","family":"Kamali","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"},{"name":"Department of Bioinformatics, School of Advanced Medical Technologies Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2233-7424","authenticated-orcid":false,"given":"Daan","family":"Dittmar","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1949-2298","authenticated-orcid":false,"given":"Harold","family":"Snieder","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0766-4382","authenticated-orcid":false,"given":"Marie L. 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