{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T04:00:57Z","timestamp":1782360057128,"version":"3.54.5"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T00:00:00Z","timestamp":1721520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Regulatory actions significantly reduced methyldibromo glutaronitrile (MDBGN)\u2010induced allergic contact dermatitis (ACD) from cosmetics in Europe. Turkey banned MDBGN in 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess sensitization and ACD rates to MDBGN before and after its ban in Turkey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 2653 consecutively patch tested patients between 1996 and 2023 with MDBGN 0.1% pet. (<jats:italic>n<\/jats:italic>\u2009=\u2009573) or 0.2%\u20130.3% pet. (<jats:italic>n<\/jats:italic>\u2009=\u20091310) or 0.5% pet. (<jats:italic>n<\/jats:italic>\u2009=\u2009770) were analysed. MDBGN was tested as MDBGN\/phenoxyethanol (PE) in 1434 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sensitization prevalence was 1.7% (45\/2653), peaking at 5.3% in 2018 and 2023 with MDBGN 0.3% pet. There was a two\u2010fold male predominance, with patients exclusively \u226520\u2009years old. None of the patients reacted to PE. ACD occurred in 0.7% (19\/2653), mainly affecting hands and linked to non\u2010occupational exposure (78.9%), particularly from rinse\u2010off\/leave\u2010on cosmetics. The pattern of \u2018middle\u2010aged men with hand eczema and fragrance allergy' was particularly notable. Occupational ACD was rare (21.1%), occurring mainly in hairdressers from hair gel. Positive reactions with current clinical relevance dropped from 48.3% (1996\u20132014) to zero after 2015 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The ban effectively reduced MDBGN\u2010induced ACD in Turkey, yet the prevalence of positive patch test reactions remains high, likely due to past exposures or other undisclosed sources. 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