{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T20:15:16Z","timestamp":1770495316659,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neomycin is an aminoglycoside antibiotic that may cause contact allergy. It was withdrawn as a medicine for human use in Denmark in October 2009 but is still found in some vaccines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify time trends in contact allergy to neomycin in the period from 2000 to 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010section study of patients \u226518\u2009years consecutively patch\u2010tested with neomycin sulfate (20% in pet.) at Gentofte Hospital, Denmark, during the period 2000\u20132023 was conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall prevalence of contact allergy to neomycin was 1.4%. The prevalence was significantly lower in the period \u20182010\u20132023\u2019 (1.2%) than in \u20182000\u20132009\u2019 (1.8%) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.005). Contact allergy to neomycin was significantly positively associated with facial dermatitis and age &gt;40\u2009years, and significantly negatively associated with occupational dermatitis and hand dermatitis. No changes in sex, occupational dermatitis, atopic dermatitis, hand dermatitis, leg dermatitis, facial dermatitis, or age\u2009&gt;\u200940\/\u226440 (the MOAHLFA\u2010index) were identified when comparing neomycin contact allergic\u2010patients in the two periods \u20182010\u20132023\u2019 and \u20182001\u20132009\u2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Neomycin is a rare cause of contact allergy in Denmark with a significantly lower prevalence following its withdrawal as a medicinal product for human use in Denmark in 2009.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14653","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T12:01:19Z","timestamp":1721736079000},"page":"392-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Contact allergy to neomycin in consecutively patch tested <scp>Danish<\/scp> eczema patients from 2000 to 2023: A cross\u2010sectional study"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2989-9198","authenticated-orcid":false,"given":"Christoffer","family":"Kursawe Larsen","sequence":"first","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital  Hellerup Denmark"},{"name":"Faculty of Health Science, Institute of Clinical Medicine University of Copenhagen  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2442-5735","authenticated-orcid":false,"given":"Mikkel Bak","family":"Jensen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital  Hellerup Denmark"},{"name":"Faculty of Health Science, Institute of Clinical Medicine University of Copenhagen  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9756-656X","authenticated-orcid":false,"given":"Jakob F. B.","family":"Schwensen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital  Hellerup Denmark"},{"name":"Faculty of Health Science, Institute of Clinical Medicine University of Copenhagen  Denmark"},{"name":"Department of Dermatology and Allergy Herlev and Gentofte Hospital  Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/PDS.1117"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2017.12.971"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/COD.12621"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/COD.14255"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/COD.14170"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/PDS.4064"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/COD.13704"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/COD.12432"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/COD.14421"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/BJD.15180"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.0105\u20101873.2004.00406.X"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475415623512"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2009.08097"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2022.29017.jdk"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000777"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ABD.2022.07.008"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAAD.2007.07.050"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119883"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2008.09.008"},{"issue":"2","key":"e_1_2_12_21_1","first-page":"78","article-title":"A comparative clinical study of sisomicin cream versus mupirocin ointment in pyodermas","volume":"68","author":"Oberai C","year":"2002","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.245.6.571b"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T02:42:08Z","timestamp":1735180928000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.14653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,23]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/cod.14653"],"URL":"https:\/\/doi.org\/10.1111\/cod.14653","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,23]]},"assertion":[{"value":"2024-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}