{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:36:51Z","timestamp":1790692611147,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patch tests (PTs) are recommended to identify the culprit drug in non\u2010immediate cutaneous adverse drug reactions (NICADRs). We recently reported that, in patients with NICADRs, a unique reading of PTs at day (D)2 compared with an additional second late reading at D4 missed almost half (45.3%) of the positive PTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the change in sensitivity of the PT reading on D4 compared with the reading on D3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective (July 2020\u2013June 2023) monocentric study of patients who had PTs with two readings for a NICADR. We compared reading on D3 and the second reading on D4 for the suspected drug (primary outcome) and for the related drugs tested simultaneously (secondary outcome).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 249 patients underwent patch testing with D3 and D4 readings. Regarding the primary outcome, the first reading at D3 was positive for 13.7% of patients, and the reading at D4 for 24.9% of patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Regarding the secondary outcome, only 9.6% of patients had all their positive PT at D3 compared with 24.9% of patients at D4 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Considering the evaluated drug classes, no statistical difference was observed. However, we highlight that D3 reading detected all positive carbamazepine PTs (<jats:italic>n<\/jats:italic>\u2009=\u20093) while positive clindamycin PTs (<jats:italic>n<\/jats:italic>\u2009=\u20094) were identified only with the help of the second reading on D4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed that, an additional D4 reading compared with a single D3 reading enhanced the sensitivity of PTs to identify culprit drugs and related. Further studies should replicate these findings and evaluate the medico\u2010economic balance and safety of a single reading of PTs on D4.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14654","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T12:44:49Z","timestamp":1722343489000},"page":"321-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Patch tests in non\u2010immediate cutaneous adverse drug reactions: Late readings on <scp>Day 4<\/scp> is more sensitive than on <scp>Day 3<\/scp>"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0627-3181","authenticated-orcid":false,"given":"Ilaria","family":"Matei","sequence":"first","affiliation":[{"name":"Dermatology Department APHP, Henri Mondor Hospital  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bettuzzi","sequence":"additional","affiliation":[{"name":"Dermatology Department APHP, Henri Mondor Hospital  Cr\u00e9teil France"},{"name":"EA7379 EpidermE, Univ Paris Est Cr\u00e9teil EpidermE  Cr\u00e9teil France"},{"name":"Reference Center for Toxic Bullous Diseases and Severe Drug Reactions  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5613-2745","authenticated-orcid":false,"given":"Amandine","family":"Weill","sequence":"additional","affiliation":[{"name":"Dermatology Department APHP, Henri Mondor Hospital  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendeline","family":"Gener","sequence":"additional","affiliation":[{"name":"Dermatology Department APHP, Henri Mondor Hospital  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamar Bel","family":"Hareth","sequence":"additional","affiliation":[{"name":"Dermatology Department APHP, Henri Mondor Hospital  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fleck","family":"Margaux","sequence":"additional","affiliation":[{"name":"Dermatology Department APHP, Henri Mondor Hospital  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Verlinde\u2010Carvalho","sequence":"additional","affiliation":[{"name":"Department of Pharmacy AP\u2010HP, H\u00f4pital Henri\u2010Mondor  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Paul","sequence":"additional","affiliation":[{"name":"EA7379 EpidermE, Univ Paris Est Cr\u00e9teil EpidermE  Cr\u00e9teil France"},{"name":"Department of Pharmacy AP\u2010HP, H\u00f4pital Henri\u2010Mondor  Cr\u00e9teil 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