{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:37:33Z","timestamp":1787884653430,"version":"build-2784847793"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Tert\u2010butylphenol (TBP) derivatives, antioxidants in adhesives and diabetes devices, may provoke allergic contact dermatitis (ACD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this study is to report sensitization to TBP derivatives in medical devices and to highlight that tert\u2010butylhydroquinone (BHQ) and tert\u2010butylcatechol (TBC) are potential screeners in this regard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen patients with ACD from adhesives and diabetes devices were patch tested to different TBPs: BHQ 1% pet., TBC 0.25% pet., BHA 2% pet., BHT 2% pet., 4\u2010tert\u2010butylphenol (TBP) 1% pet. and 2,4\u2010di\u2010tert\u2010butylphenol (di TBP) 1% pet. The culprit devices (medical adhesives, sanitary pads, diabetes devices) and TBP patch preparations were analysed using gas chromatography\u2010mass spectrometry (GC\u2013MS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BHQ (9\/13), TBC (7\/13), and to a lesser extent BHT (3\/15), BHA (2\/15) and TBP (2\/13) gave positive reactions. Seven patients had developed ACD from adhesives and diabetes devices, respectively, and one patient from sanitary pads. GC\u2013MS analyses of the medical devices and patch test materials confirmed the presence of the patch\u2010test positive TBPs, or chemically related derivatives, or, interestingly, tert\u2010butylbenzoquinones (BBQ) were found, that is, spontaneously formed, highly reactive TBP metabolites, likely (pseudo\u2010) cross reacting with the patch tested TBPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TBPs might be overlooked sensitizers in medical devices, and BHQ and TBC are potential screeners in this regard.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14670","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T03:15:10Z","timestamp":1724296510000},"page":"387-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Tert\u2010butylhydroquinone and tert\u2010butylcatechol positivity as warning lights of skin sensitization to tert\u2010butylphenol derivatives in adhesives and diabetes devices"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3489-8010","authenticated-orcid":false,"given":"Ella","family":"Dendooven","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Antwerp (UZA) and University of Antwerp (UA)  Antwerp Belgium"},{"name":"Natural Products and Food Research and Analysis\u2013Pharmaceutical Technology, Department of Pharmaceutical Sciences University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Naessens","sequence":"additional","affiliation":[{"name":"Natural Products and Food Research and Analysis\u2013Pharmaceutical Technology, Department of Pharmaceutical Sciences University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenn","family":"Foubert","sequence":"additional","affiliation":[{"name":"Natural Products and Food Research and Analysis\u2013Pharmaceutical Technology, Department of Pharmaceutical Sciences University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Hermans","sequence":"additional","affiliation":[{"name":"Natural Products and Food Research and Analysis\u2013Pharmaceutical Technology, Department of Pharmaceutical Sciences University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0076-2887","authenticated-orcid":false,"given":"Olivier","family":"Aerts","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Antwerp (UZA) and University of Antwerp (UA)  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476910701680236"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13649"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14335"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13706"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14187"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13750"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1984.tb01007.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14141"},{"key":"e_1_2_9_11_1","unstructured":"Available at:https:\/\/ntp.niehs.nih.gov\/sites\/default\/files\/ntp\/htdocs\/st_rpts\/tox070.pdf. 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