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However, while accelerator\u2010free rubber gloves are available, they still cause ACD in some individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>A new allergen, 2\u2010cy\u0430n\u043eethyl dimethyldithiocarbamate, (CEDMC), has recently been identified in accelerator\u2010free gloves, and we here provide a first in vitro characterisation of CEDMC in a dendritic cell (DC)\u2010like cell model along with three reference sensitizer rubber chemicals, consisting of tetraethylthiuram disulfide (TETD) and two xanthogenates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cellular responses after the exposure to the rubber chemicals were assessed using a transcriptomic approach, multiplex cytokine secretion profiling, and flow cytometry to determine DC model activation marker expression and apoptosis induction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CEDMC and all other sensitizers were classified as strong skin sensitizers with the transcriptomic approach. They all significantly increased IL\u20108 secretion and exposure to all except one increased CD86 DC activation marker expression. When tested, CEDMC induced apoptosis, however, delayed compared to TETD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The in vitro data corroborate CEDMC, TETD, and investigated xanthogenates as skin sensitizers. Transcriptomic analyses further reveal unique cellular responses induced by CEDMC, which together with future study can contribute to better understanding of cellular mechanisms underlying the sensitising capacity of rubber chemicals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.14682","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T02:08:31Z","timestamp":1724638111000},"page":"61-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["In vitro characterisation of a novel rubber contact allergen in protective gloves"],"prefix":"10.1111","volume":"92","author":[{"given":"Renato Ivan","family":"de \u00c1vila","sequence":"first","affiliation":[{"name":"Department of Immunotechnology Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5401-2435","authenticated-orcid":false,"given":"Linda","family":"Ljungberg Silic","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology (DOED) Lund University, Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"Carreira\u2010Santos","sequence":"additional","affiliation":[{"name":"Department of Immunotechnology Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Mer\u00e9nyi","sequence":"additional","affiliation":[{"name":"Department of Immunotechnology Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Bergendorff","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology (DOED) Lund 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