{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:49:45Z","timestamp":1782125385994,"version":"3.54.5"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Existing literature has questioned the sensitivity of patch testing (PT) with cotrimoxazole (CTX) in the study of drug hypersensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Assess the sensitivity of PT with CTX in non\u2010immediate cutaneous adverse drug reactions (CADR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Materials\/Methods<\/jats:title><jats:p>Retrospective analysis (2000\u20132022) of PT with an antibiotic series including CTX 10% pet (Chemotechnique Diagnostics\u00a9) performed according to ESCD guidelines in patients with suspected non\u2010immediate CADR reactions to CTX. Some patients were additionally tested with in\u2010house preparations of CTX from Bactrim DS\u00ae tablets at 10% in pet or water and trimethoprim 10% pet (Laborat\u00f3rios Edol\u00a9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010four patients (48F\/16M; mean age 47\u2009\u00b1\u200918) were included, mostly with maculopapular exanthema (51, 80%). Notably, CTX was sole suspect in 24 patients. There was no positive reaction to CTX at 10% from Chemotechnique or Bactrim DS\u00ae tablets prepared at 10% pet for patch testing. One patient reacted exclusively to trimethoprim with 1+ reaction. Two patients had a faint reaction (1+) only with the powder of Bactrim DS\u00ae tablets in water at D2, but as the reactions faded completely in 24 or 48\u2009h, they were interpreted as irritant non\u2010specific reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that patch testing may lack sufficient sensitivity to diagnose CTX\u2010induced non\u2010immediate CADR. Therefore, clinicians should be cautious interpreting CTX patch test results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14692","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T06:59:42Z","timestamp":1725519582000},"page":"503-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Patch testing in non\u2010immediate hypersensitivity to cotrimoxazole: Is it useful?"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2642-1773","authenticated-orcid":false,"given":"Jo\u00e3o Nuno","family":"Soares","sequence":"first","affiliation":[{"name":"Dermatology Department Hospitais da Universidade de Coimbra, Unidade Local de Sa\u00fade de Coimbra  Coimbra Portugal"},{"name":"Faculdade de Medicina Universidade de Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Pedro","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospitais da Universidade de Coimbra, Unidade Local de Sa\u00fade de Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospitais da Universidade de Coimbra, Unidade Local de Sa\u00fade de Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Castro","family":"Pinho","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospitais da Universidade de Coimbra, Unidade Local de Sa\u00fade de Coimbra  Coimbra Portugal"},{"name":"Faculdade de Medicina Universidade de Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6842-1360","authenticated-orcid":false,"given":"Margarida","family":"Gon\u00e7alo","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospitais da Universidade de Coimbra, Unidade Local de Sa\u00fade de Coimbra  Coimbra Portugal"},{"name":"Faculdade de Medicina Universidade de Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1939-4551-6-18"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.12.901"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13562"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13796"},{"key":"e_1_2_9_8_1","unstructured":"SoaresJ Gon\u00e7aloM.Decoding \u03b2\u2010lactam cross\u2010reactivity: longitudinal skin testing from 2015\u20132022 [Internet]. American Academy of Dermatology Annual Meeting San Diego CA; 2024. Accessed May 31 2024.https:\/\/www.aad.org\/member\/meetings-education\/am24\/education"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14090"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.05.034"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60037-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfaa182"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.10.021"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000058337"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14692","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T05:25:05Z","timestamp":1744349105000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.14692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,4]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/cod.14692"],"URL":"https:\/\/doi.org\/10.1111\/cod.14692","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,4]]},"assertion":[{"value":"2024-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}