{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:04:33Z","timestamp":1773965073965,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100023331","name":"LEO Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Hand Eczema Severity Index (HECSI) is a Clinician\u2010Reported Outcome measure of the severity of hand eczema (HE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the validity, reliability and ability to detect change of the HECSI, and the HECSI\u201075 and HECSI\u201090 as responder definitions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Analyses were performed using data from a sample of\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009258 patients with Chronic Hand Eczema (CHE) from a Phase 2b, randomised, double\u2010blind, vehicle\u2010controlled trial of delgocitinib cream, pooled across treatment groups. The measurement properties of the HECSI were assessed and the adequacy of the HECSI\u201075 and HECSI\u201090 as responder definitions was explored through cross\u2010tabulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Inter\u2010item correlations provided support for the scoring, whereby items are grouped by areas of the hand. HECSI demonstrated good test\u2013retest reliability with intra\u2010class correlations\u2009&gt;0.70. Construct validity was supported by a logical pattern of correlations with concurrent measures and significant differences in HECSI scores across severity groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). HECSI was responsive with statistically significant improvements over time and with significant differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) between improved and stable groups. Data provided support for both HECSI\u201075 and HECSI\u201090 as within\u2010patient responder definitions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HECSI has strong validity, reliability and ability to detect change as a measure of CHE severity. HECSI\u201075 and HECSI\u201090 are appropriate responder definitions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.14699","type":"journal-article","created":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T20:28:53Z","timestamp":1728851333000},"page":"51-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of validity, reliability and ability to detect change for the Hand Eczema Severity Index (\n                    <scp>HECSI<\/scp>\n                    ) and evaluation of\n                    <scp>HECSI<\/scp>\n                    \u201075 and\n                    <scp>HECSI<\/scp>\n                    \u201090 as within\u2010patient responder definitions"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1289-1827","authenticated-orcid":false,"given":"Yasemin Topal","family":"Y\u00fcksel","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Bispebjerg Hospital, University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Thoning","sequence":"additional","affiliation":[{"name":"LEO Pharma A\/S  Ballerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lotte Seiding","family":"Larsen","sequence":"additional","affiliation":[{"name":"LEO Pharma A\/S  Ballerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucine","family":"Lehmann","sequence":"additional","affiliation":[{"name":"LEO Pharma A\/S  Ballerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0345-2523","authenticated-orcid":false,"given":"Rob","family":"Arbuckle","sequence":"additional","affiliation":[{"name":"Adelphi Values Patient\u2010Centered Outcomes  Cheshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Grant","sequence":"additional","affiliation":[{"name":"Adelphi Values Patient\u2010Centered Outcomes  Cheshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7543-8299","authenticated-orcid":false,"given":"Tove","family":"Agner","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Bispebjerg Hospital, University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14303"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/tcrm.S292504"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14035"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010019\u201001164\u20105"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13212"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2009.09463.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06305.x"},{"key":"e_1_2_9_9_1","unstructured":"HECOS Working Group.https:\/\/www.c3outcomes.org\/"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14982"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13828"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21037"},{"key":"e_1_2_9_13_1","unstructured":"HECSI.https:\/\/hecsiscore.com\/"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2008.08487.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010024\u201002818\u20103"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12819"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21041"},{"key":"e_1_2_9_19_1","unstructured":"European Medicines Agency (EMA).Reflection Paper on the Regulatory Guidance for the Use of Health\u2010Related Quality of Life (HRQL) Measures in the Evaluation of Medicinal Products. 2005.http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2009\/09\/WC500003637.pdf"},{"key":"e_1_2_9_20_1","unstructured":"US Food and Drug Administration (FDA).Patient\u2010Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims. 2009.https:\/\/www.fda.gov\/downloads\/drugs\/guidances\/ucm193282.pdf"},{"key":"e_1_2_9_21_1","unstructured":"US Food and Drug Administration (FDA).Patient\u2010Focused Drug Development: Collecting Comprehensive and Representative Input. 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