{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:51:09Z","timestamp":1792414269930,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patch test results may be influenced by age\u2010related factors. However, there is still discordant evidence between age and patch test results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aim to evaluate the patch test results reflecting skin sensitisation, their relevance and association with clinical features by age group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective multicentric study of all patients patch tested with the Spanish baseline series in participating centres. Age groups were pre\u2010defined as children (0\u2010 to 11\u2010years), adolescents (12\u2010 to 18\u2010years), young adults (19\u2010 to 30\u2010years), middle\u2010aged adults (31\u2010 to 65\u2010years) and older adults (\u226566\u2010years). Occurrence of sensitisation, relevance and clinical features were compared by age group. Factors associated with skin sensitisation were investigated with multivariate logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 13\u2009368 patients were patch\u2010tested. Differences in positive patch test results and relevance by age were detected with the highest proportion in middle\u2010aged adults. Age\u2010related trend differences were found for nickel, potassium dichromate, caines, colophony, <jats:italic>Myroxylon pereirae<\/jats:italic> resin, 2\u2010hydroxyethyl methacrylate and limonene hydroperoxide. The multivariate logistic analysis (adjusted for sex, atopic dermatitis, body location and occupational dermatitis) showed an association between the age group of 31\u201365 (OR: 1.41, 95% CI: 1.26\u20131.58) and above 66\u2010years (OR: 1.15, 95% CI: 1.01\u20131.32) with a higher proportion of positive results, compared with young adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Positive patch test results vary according to age, with the highest occurrence in middle\u2010aged adults. Most haptens did not present age\u2010related differences, reinforcing the use of baseline series regardless of age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14702","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T12:40:52Z","timestamp":1728736852000},"page":"120-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Patch test results to the Spanish baseline patch test series according to age groups: A multicentric prospective study from 2019 to 2023"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5821-9780","authenticated-orcid":false,"given":"David","family":"Pesqu\u00e9","sequence":"first","affiliation":[{"name":"Servicio de Dermatolog\u00eda Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Departament de Medicina Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona 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