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HaCaT cells were treated with allergens (10\u2009\u03bcM) for 24\u2009h and the cellular lipid extracts were analysed by C18 liquid chromatography with tandem mass spectrometry (LC\u2013MS\/MS). Data analysis was performed using Lipostar software. Statistical analysis was carried out using Metaboanalyst and R software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All three sensitisers used caused significant changes in the lipidome of HaCaT cells in a similar trend. There was an upregulation in several plasmanyl\/plasmenyl phospholipids (O\u2010\/P\u2010phosphatidylcholines [PC] and O\u2010\/P\u2010phosphatidylethanolamines [PE]), sphingolipids (HexCer) and triacylglycerol lipid species, and a decrease in some polyunsaturated fatty acids\u2010containing phospholipid (PE and PC) species suggesting oxidative stress and inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study is the first to evaluate the plasticity of the HaCaT cell lipidome in response to allylic hydroperoxide allergens Lim\u20102\u2010OOH and Lin\u20106\/7\u2010OOH, together with the experimental contact allergen DNFB. These allergens are able to upregulate and downregulate certain lipid classes to a varying degree.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.14711","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T18:46:32Z","timestamp":1729017992000},"page":"176-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A lipidomic approach towards identifying the effects of fragrance hydroperoxides on keratinocytes"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7443-1792","authenticated-orcid":false,"given":"Aaron I.","family":"Moore","sequence":"first","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences, Panoz Institute and Trinity Biomedical Sciences Institute, Trinity College Dublin The University of Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4745-0984","authenticated-orcid":false,"given":"Ana S. 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