{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T05:35:38Z","timestamp":1768714538664,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Allergic contact dermatitis (ACD) induced by topical application of neomycin is frequently reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This multi\u2010center study investigated prevalence and determinants of neomycin sensitisations in 30\u2009629 outpatients from North\u2010eastern Italy during 1997\u20132021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>European baseline and extended Triveneto series were applied on the upper back of patients patch testing for suspected ACD and removed after 48\u2009h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prevalence of neomycin sensitisation was 2.29% (=701\/30\u2009629), significantly decreasing over time, especially after 2003. Neomycin sensitisation increased with age, especially in female patients older than 60 with leg dermatitis. The majority of patients sensitised to neomycin (74.5%) tested positive also against other haptens, particularly ingredients included in creams and emollients, as lanolin or benzocaine or preservatives as thimerosal or parabens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The decreasing prevalence of neomycin sensitisation over time likely reflected reduced accessibility and circulation of neomycin in Italy, due to containment of prescriptions and over\u2010the\u2010counter accessibility. Older individuals are typically more likely to be treated by topical medications and antibiotics as neomycin for various conditions, including stasis dermatitis. Since ACD caused by topical medications is relatively easy to miss, comprehensive drug history and patch testing are essential for any patient with suspected sensitisation caused by neomycin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14730","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T01:23:11Z","timestamp":1736385791000},"page":"460-468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence and Determinants of Sensitisation to Neomycin in North\u2010Eastern Italy, 1997\u20132021"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6285-7355","authenticated-orcid":false,"given":"Luca","family":"Cegolon","sequence":"first","affiliation":[{"name":"Department of Medical, Surgical &amp; Health Sciences University of Trieste  Trieste Italy"},{"name":"Public Health Department University Health Agency Giuliano\u2010Isontina (ASUGI)  Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7717-0417","authenticated-orcid":false,"given":"Francesca","family":"Larese Filon","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical &amp; Health Sciences University of Trieste  Trieste Italy"},{"name":"Occupational Medicine Unit University Health Agency Giuliano\u2010Isontina (ASUGI)  Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the North\u2010East Research Group on Contact Dermatitis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2022.07.008"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2009.09073"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2000.043005295.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.12894"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2020.1805671"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.46747\/cfp.6706414"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475415623512"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04662.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1981.03310310017008"},{"key":"e_1_2_11_11_1","first-page":"145","volume-title":"Fischer's Contact Dermatitis","author":"Atwater A. 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