{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:22:19Z","timestamp":1793190139333,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Octylisothiazolinone (OIT; CAS 26530\u201320\u20101) is used as a biocide in leather products.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To report several cases of allergic contact dermatitis (ACD) from the use of headphones containing OIT, and to highlight the strong allergic potential of this preservative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Four patients with ACD from headphones were patched tested using the European baseline, cosmetic, rubber, plastics\/glues and acrylates series. Patients were also tested to different parts of their own headphones (\u2018as is\u2019). Chemical analyses of the headphones was additionally performed with Ultra Performance Liquid Chromatography\u2014tandem mass spectrometry (UPLC\u2010MS\/MS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients had developed localised ACD to the contact sites of the headphones, except for one patient who developed \u2018angioedema\u2010like\u2019 dermatitis. All patients were shown to have been primarily sensitised to OIT. UPLC\u2010MS\/MS analysis confirmed OIT in the leather ear pads of the headphones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>OIT is a relevant and strong sensitizer in leather, and may cause severe ACD. Safer use concentrations (limits) of OIT, as well as product labelling in the leather industry, may be required to ensure a better protection of consumers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14733","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T07:58:40Z","timestamp":1733903920000},"page":"291-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Severe Allergic Contact Dermatitis From Octylisothiazolinone in Over\u2010Ear Headphones: A Case Series"],"prefix":"10.1111","volume":"92","author":[{"given":"Marion","family":"Menanteau","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Diseases Hotel\u2010Dieu Hospital, AP\u2010HP Centre \u2013 Universit\u00e9 Paris Cit\u00e9, AP\u2010HP  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9, CRESS\u2010INSERM UMR\u20101153, HERA Team  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8608-1007","authenticated-orcid":false,"given":"Go\u00ebl","family":"Fenech","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Diseases Hotel\u2010Dieu Hospital, AP\u2010HP Centre \u2013 Universit\u00e9 Paris Cit\u00e9, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Dermatology Centre Hospitalier Universitaire  Lille France"},{"name":"Department of Dermatology Centre Hospitalier  Valenciennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddy","family":"Langlois","sequence":"additional","affiliation":[{"name":"Pollutants Metrology Department Institut National de Recherche et S\u00e9curit\u00e9  Vandoeuvre\u2010les\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5997-1181","authenticated-orcid":false,"given":"Pierre","family":"Marcant","sequence":"additional","affiliation":[{"name":"Department of Dermatology Centre Hospitalier Universitaire  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Pollutants Metrology Department Institut National de Recherche et S\u00e9curit\u00e9  Vandoeuvre\u2010les\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Staumont\u2010Sall\u00e9","sequence":"additional","affiliation":[{"name":"Department of Dermatology Centre Hospitalier Universitaire  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Bensefa\u2010Colas","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Diseases Hotel\u2010Dieu Hospital, AP\u2010HP Centre \u2013 Universit\u00e9 Paris Cit\u00e9, AP\u2010HP  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9, CRESS\u2010INSERM UMR\u20101153, HERA Team  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9824-1034","authenticated-orcid":false,"given":"Marie\u2010No\u00eblle","family":"Crepy","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Diseases Hotel\u2010Dieu Hospital, AP\u2010HP Centre \u2013 Universit\u00e9 Paris Cit\u00e9, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14036"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15954"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000735"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14528"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14523"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12068"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12670"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14641"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1983.tb04473.x"},{"key":"e_1_2_10_11_1","unstructured":"\u201cCLH Report\u2010Proposal for Harmonized Classification and Labelling. Substance Name: Octhilinone (ISO); 2\u2010Octyl\u20102H\u2010Isothiazol\u20103\u2010One; [OIT] \u201dhttps:\/\/echa.europa.eu\/documents\/10162\/df62dc1e\u2010b657\u2010a288\u20107050\u2010b7763e8ec8eb."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12249"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247563"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13905"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13661"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1996.tb02155.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12347"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12741"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14255"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T07:43:48Z","timestamp":1741765428000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.14733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,10]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/cod.14733"],"URL":"https:\/\/doi.org\/10.1111\/cod.14733","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,10]]},"assertion":[{"value":"2024-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}