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It is an allergen of interest as it has a widespread use in over\u2010the\u2010counter and prescription products globally, but geographical variations may exist. This study aimed to establish prevalence estimates of CA to neomycin in dermatitis patients and to investigate potential geographical variations. Three databases (PubMed, Embase, and Web of Science) were screened, revealing 70 included studies comprising 456\u2009372 adults and 17\u2009720 children who underwent patch testing. The pooled prevalence of CA to neomycin was found to be 3.2% (95% confidence interval [CI]: 2.6%\u20133.8%) in adults and 4.3% (95% CI: 2.65%\u20136.3%) in children. The highest prevalences were observed in North America (adults: 6.4%; children: 8.1%) and South Asia (adults: 4.9%), while Europe showed lower rates (adults: 2.5%; children: 0.8%). Studies after the year 2000 indicated a prevalence of 2.1% in adults and 5.1% in children across geographical regions. These findings highlight a public health concern, particularly in regions with high prevalence rates. The study underscores the need for more restrictive use of neomycin to reduce the incidence of neomycin\u2010induced CA.<\/jats:p>","DOI":"10.1111\/cod.14784","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T19:39:46Z","timestamp":1742413186000},"page":"1-15","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence of Contact Allergy to Neomycin in Dermatitis Patients: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2442-5735","authenticated-orcid":false,"given":"Mikkel Bak","family":"Jensen","sequence":"first","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital  Copenhagen Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health Science University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2780-3604","authenticated-orcid":false,"given":"Daniel","family":"Isufi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Herlev and Gentofte \u2010 Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2989-9198","authenticated-orcid":false,"given":"Christoffer Kursawe","family":"Larsen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital  Copenhagen Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health Science University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9756-656X","authenticated-orcid":false,"given":"Jakob Ferl\u00f8v Baselius","family":"Schwensen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Health Science University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1527-4242","authenticated-orcid":false,"given":"Farzad","family":"Alinaghi","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital  Copenhagen Denmark"},{"name":"Department of Dermatology and Allergy Herlev and Gentofte \u2010 Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-8463","authenticated-orcid":false,"given":"Jeanne Duus","family":"Johansen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/PDS.1117"},{"key":"e_1_2_10_3_1","first-page":"1046","volume-title":"Neomycin. 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