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CoU is categorised into non\u2010immunologic (NI\u2010CoU) and immunologic (I\u2010CoU) types, with I\u2010CoU potentially leading to anaphylaxis. Both forms of CoU can be associated with protein contact dermatitis and the CoU syndrome. Patients with I\u2010CoU may also have other type I (immediate) allergic diseases, such as allergic conjunctivitis, rhinitis, asthma or food allergy. This review provides a detailed overview of CoU and related conditions, focusing on triggers, diagnostic methods and management strategies. NI\u2010CoU is typically triggered by low molecular weight chemicals, while I\u2010CoU involves IgE\u2010mediated hypersensitivity to both high molecular weight proteins and low molecular weight chemicals. Early diagnosis is crucial, though CoU is often underrecognized. The diagnostic approach includes a thorough medical history, physical examination, evaluation of photographs, (non)invasive skin tests and in\u00a0vitro assessments. Management strategies prioritise trigger avoidance and pharmacological treatments when avoidance is not fully possible. For I\u2010CoU, second\u2010generation H<jats:sub>1<\/jats:sub>\u2010antihistamines are the first\u2010line treatment. Severe cases of I\u2010CoU may benefit from anti\u2010IgE therapy (omalizumab). Patients at risk of anaphylaxis should carry an adrenaline auto\u2010injector and wear a medical alert bracelet.<\/jats:p>","DOI":"10.1111\/cod.14794","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T10:02:08Z","timestamp":1743760928000},"page":"87-107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Contact Urticaria and Related Conditions: Clinical Review"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2595-468X","authenticated-orcid":false,"given":"Mojca","family":"Bizjak","sequence":"first","affiliation":[{"name":"Division of Allergy University Clinic of Respiratory and Allergic Diseases Golnik  Golnik Slovenia"},{"name":"Faculty of Medicine, University of Maribor  Maribor Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0076-2887","authenticated-orcid":false,"given":"Olivier","family":"Aerts","sequence":"additional","affiliation":[{"name":"Department of Dermatology  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5821-9780","authenticated-orcid":false,"given":"David","family":"Pesqu\u00e9","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital del Mar Research Institute, Department of Medicine Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3386-4502","authenticated-orcid":false,"given":"Melba","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Institute of Allergology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health  Berlin Germany"},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology ITMP Immunology and Allergology  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8277-1700","authenticated-orcid":false,"given":"Riccardo","family":"Asero","sequence":"additional","affiliation":[{"name":"Clinica San Carlo Ambulatorio di Allergologia  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6842-1360","authenticated-orcid":false,"given":"Margarida","family":"Gon\u00e7alo","sequence":"additional","affiliation":[{"name":"Clinic of Dermatology University Hospital, Coimbra Local Health Unit and Faculty of Medicine, University of Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7580-0684","authenticated-orcid":false,"given":"Thomas","family":"Rustemeyer","sequence":"additional","affiliation":[{"name":"Dermato\u2010Allergology and Occupational Dermatology Amsterdam University Medical Centers  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4701-7374","authenticated-orcid":false,"given":"Mitja","family":"Ko\u0161nik","sequence":"additional","affiliation":[{"name":"Division of Allergy University Clinic of Respiratory and Allergic Diseases Golnik  Golnik Slovenia"},{"name":"Faculty of Medicine, University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2035-6998","authenticated-orcid":false,"given":"Mark","family":"Ka\u010dar","sequence":"additional","affiliation":[{"name":"Division of Allergy University Clinic of Respiratory and Allergic Diseases Golnik  Golnik Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-3439","authenticated-orcid":false,"given":"An","family":"Goossens","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Catholic University of Leuven (KU Leuven)  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3504-2473","authenticated-orcid":false,"given":"Jose Hern\u00e1n","family":"Alfonso","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; 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