{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:35:23Z","timestamp":1790879723665,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>(Meth)acrylates are well\u2010known causes of allergic contact dermatitis, and nail products are the major source of exposure, especially in a non\u2010occupational setting. In 2020, the European legislation restricted 2\u2010hydroxyethyl methacrylate (2\u2010HEMA) only in nail cosmetics to professional use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the Italian prevalence trend of positive patch test reactions to 2\u2010HEMA, the best marker for delayed hypersensitivity to (meth)acrylates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective descriptive study on consecutive patients patch tested with the Italian baseline series containing 2\u2010HEMA was performed in 8 Italian Dermatology Clinics. Demographics, patch test results, exposure settings and sources were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Amongst 7133 patch tested patients, 147 (2.1%) resulted positive to 2\u2010HEMA with an increasing trend from 2019 (1.6%) to 2023 (2.7%). The median age of sensitised female patients with a relevant positive patch test reaction to 2\u2010HEMA was significantly decreasing over time (<jats:italic>p<\/jats:italic>\u2009=\u20090.004). Non\u2010occupational allergic contact dermatitis was documented in 68.7%; artificial nails were the leading source of exposure in both occupational (75.0%) and non\u2010occupational (72.2%) settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of contact allergy to 2\u2010HEMA in Italy shows a progressively increasing trend over time. Currently, the European legislation does not appear to be effective in preventing or reducing this phenomenon.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14800","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:44:49Z","timestamp":1747874689000},"page":"224-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Italian Trend of Contact Allergy to 2\u2010Hydroxyethyl Methacrylate: Is the Current European Legislation Working?"],"prefix":"10.1111","volume":"93","author":[{"given":"Elena Sofia","family":"Caroppo","sequence":"first","affiliation":[{"name":"Dermatology Section, Department of Medicine and Surgery University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Casciola","sequence":"additional","affiliation":[{"name":"Dermatology Section, Department of Medicine and Surgery University of Perugia  Perugia 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cataldo","family":"Patruno","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences Vincenzo Tiberio University of Molise  Campobasso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5559-9722","authenticated-orcid":false,"given":"Paolo","family":"Romita","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Precision and Regenerative Medicine and Jonian Area University Aldo Moro of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Schena","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medicine University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Trave","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Health Sciences University of Genoa, IRCCS, Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8838-048X","authenticated-orcid":false,"given":"Leonardo","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Dermatology Section, Department of Medicine and Surgery University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-8141","authenticated-orcid":false,"given":"Luca","family":"Stingeni","sequence":"additional","affiliation":[{"name":"Dermatology Section, Department of Medicine and Surgery University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"2\u2010HEMA Study 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