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They are moderate to strong contact allergens associated with allergic contact dermatitis (ACD). Through the cleavage of their oxygen\u2013oxygen bond, they have the potential to induce lipid peroxidation (LPO). However, the role of oxidised lipids in the context of ACD is largely unexplored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Herein, the capacity of terpene hydroperoxides derived from linalool (Lin\u20106\/7\u2010OOH), geraniol (Ger\u20106\/7\u2010OOH), and limonene (Lim\u20102\u2010OOH) to induce LPO was evaluated using liposomes in a biomimetic metal\u2010catalysed oxidation system. LPO products were identified and quantified by liquid chromatography\u2010mass spectrometry (LC\u2010MS) and Tandem MS (MS\/MS). The C11\u2010BODIPY<jats:sup>581\/591<\/jats:sup> ratio\u2010fluorescence probe was also used to assess the capacity of terpene hydroperoxides to cause LPO in\u00a0vitro using a human epidermal keratinocyte cell line (HaCaT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LC\u2010MS\/MS analysis identified 14 LPO products (long\u2010chain and short\u2010chain) formed under metal\u2010catalysed oxidation mediated by terpene hydroperoxides. All hydroperoxides tested at 50\u2009mM caused significant LPO, with Lim\u20102\u2010OOH exhibiting exceptionally high oxidising potential. The C11\u2010BODIPY<jats:sup>581\/591<\/jats:sup> ratio\u2010fluorescence assay also revealed higher oxidation associated with Lim\u20102\u2010OOH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This work shows the ability of terpene hydroperoxide allergens to cause LPO, raising the possibility that LPO products may act as effectors in the pathogenesis of ACD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14804","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T20:22:11Z","timestamp":1746130931000},"page":"16-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Terpene Hydroperoxides as Lipid Peroxidation Inducers: Biomimetic and <scp>HaCaT<\/scp> Cell Studies in Allergic Contact Dermatitis"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7443-1792","authenticated-orcid":false,"given":"Aaron I.","family":"Moore","sequence":"first","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences Trinity Biomedical Sciences Institute, Trinity College Dublin, the University of Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4745-0984","authenticated-orcid":false,"given":"Ana S. 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