{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:54:31Z","timestamp":1791208471181,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alkyl glucosides are surfactants commonly found in cosmetics and household products. However, data on glucoside contact allergy in paediatric populations is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the prevalence, relevance and clinical characteristics of contact allergy to glucosides in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of the files of paediatric patients (\u2264\u200916\u2009years) who underwent patch testing for decyl glucoside (DG) and\/or lauryl glucoside (LG) at the Antwerp University Hospital (UZA) in the period between January 2018 and December 2024.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 241 children tested for DG, 148 (61.4%) were also tested for LG. DG reactions were observed in 47 patients (19.5%), with 27 (11.2%) considered positive. LG reactions occurred in 17\/148 (13%), but only 4 (2.7%) were positive, all with concomitant DG reactions. Most positive DG reactions were weak (+) (25\/27), whereas only 2 were strong (++). The median age was 7\u2009years (range: 2\u201315), with 51.9% female. Culprit sources mostly included cosmetics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patch test reactions to glucosides readily occur in children, and the positivity rate is surprisingly high. Besides many irritant and doubtful reactions, false\u2010positive (+) reactions likely occur, particularly in young atopic children. Careful interpretation of positive results and complementary work\u2010up may thus be necessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14812","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:28:04Z","timestamp":1747787284000},"page":"148-158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Frequent Positive Patch Test Reactions to Glucosides in Children: A Call for Caution?"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-2725","authenticated-orcid":false,"given":"Silada","family":"Kanokrungsee","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Antwerp (UZA) and Research Group Immunology, INFLA\u2010MED Centre of Excellence, University of Antwerp  Antwerp Belgium"},{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9813-8970","authenticated-orcid":false,"given":"Julie","family":"Leysen","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Antwerp (UZA) and Research Group Immunology, INFLA\u2010MED Centre of Excellence, University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0076-2887","authenticated-orcid":false,"given":"Olivier","family":"Aerts","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Antwerp (UZA) and Research Group Immunology, INFLA\u2010MED Centre of Excellence, University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3489-8010","authenticated-orcid":false,"given":"Ella","family":"Dendooven","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Antwerp (UZA) and Research Group Immunology, INFLA\u2010MED Centre of Excellence, University of Antwerp  Antwerp 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