{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:41:12Z","timestamp":1775079672274,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007036","name":"Milj\u00f8styrelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007036","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rubber accelerators found in rubber gloves may cause contact allergy and thus allergic contact dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate which doses of tetraethylthiuram disulfide (TETD) elicit allergic contact dermatitis by patch testing and in a repeated occluded application test simulating glove use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>A multicentre study was conducted. Eight patients with contact allergy to TETD and eight controls comprised the study group. Doses of TETD 1% (400\u2009\u03bcg\/cm<jats:sup>2<\/jats:sup>), 0.33% (130\u2009\u03bcg\/cm<jats:sup>2<\/jats:sup>), 0.11% (44\u2009\u03bcg\/cm<jats:sup>2<\/jats:sup>), 0.037% (15\u2009\u03bcg\/cm<jats:sup>2<\/jats:sup>), 0.012% (4.9\u2009\u03bcg\/cm<jats:sup>2<\/jats:sup>), 0.0041% (1.6\u2009\u03bcg\/cm<jats:sup>2<\/jats:sup>) and pure vehicle (petrolatum) were used for the patch test. Doses of TETD 1% (39\u2009\u03bcg\/cm<jats:sup>2<\/jats:sup>), 0.33% (13\u2009\u03bcg\/cm<jats:sup>2<\/jats:sup>), 0.11% (4.3\u2009\u03bcg\/cm<jats:sup>2<\/jats:sup>) and pure vehicle (99:1 ethanol: water) were used for the repeated occluded application test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three patients (3\/8) reacted to the lowest TETD dose of 0.0041% (1.6\u2009\u03bcg\/cm<jats:sup>2<\/jats:sup>) in the patch test. All patients reacted to all doses of TETD in the repeated occluded application test, none to the vehicle. The patch test dose of TETD that elicited allergic contact dermatitis in 10% of the patients (ED<jats:sub>10<\/jats:sub>) was estimated to be 0.75\u2009\u03bcg\/cm<jats:sup>2<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A content of 0.75\u2009\u03bcg\/cm<jats:sup>2<\/jats:sup> TETD in rubber gloves may elicit allergic contact dermatitis. We suggest that future studies investigating contact allergy to rubber accelerators should base their methodology on the repeated occluded application test design presented in this study.<\/jats:p><jats:p>\n<jats:bold>Trial Registration:<\/jats:bold> <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrial.gov\">ClinicalTrial.gov<\/jats:ext-link> identifier: NCT06042309<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14817","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T03:45:31Z","timestamp":1747367131000},"page":"138-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Thresholds for Contact Allergy to a Rubber Accelerator: <scp>TETD<\/scp>\u2014Determined by Serial Dilution Patch Testing and a Simulated Glove\u2010Use Model"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2989-9198","authenticated-orcid":false,"given":"Christoffer","family":"Kursawe Larsen","sequence":"first","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital  Hellerup Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health Science, University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Dermatology and Allergy Herlev and Gentofte Hospital  Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-8463","authenticated-orcid":false,"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital  Hellerup Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health Science, University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Dermatology and Allergy Herlev and Gentofte Hospital  Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Zachariae","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital  Hellerup Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health Science, University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Dermatology and Allergy Herlev and Gentofte Hospital  Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4797-0269","authenticated-orcid":false,"given":"Cecilia","family":"Svedman","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola","family":"Bergendorff","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8710-0829","authenticated-orcid":false,"given":"Charlotte G.","family":"Mortz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Center Odense University Hospital, University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9756-656X","authenticated-orcid":false,"given":"Jakob F. 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